DPP-4
シグナル伝達経路
研究分野
- 阻害剤の選択性比較
- 溶解度
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S4002 | Sitagliptin phosphate monohydrate | 41 mg/mL | 100 mg/mL | <1 mg/mL |
| S3031 | Linagliptin | <1 mg/mL | 17 mg/mL | 1 mg/mL |
| S3033 | Vildagliptin (LAF-237) | 60 mg/mL | 60 mg/mL | 60 mg/mL |
| S1540 | Saxagliptin | 63 mg/mL | 63 mg/mL | 24 mg/mL |
| S2868 | Alogliptin（SYK-322）benzoate | 2 mg/mL | 68 mg/mL | <1 mg/mL |
| S5079 | Sitagliptin | -1 mg/mL | 81 mg/mL | -1 mg/mL |
| S5063 | Trelagliptin succinate | 95 mg/mL | 95 mg/mL | 5 mg/mL |
| S8565 | Omarigliptin (MK-3102) | <1 mg/mL | 79 mg/mL | <1 mg/mL |
| S7513 | Trelagliptin | <1 mg/mL | 71 mg/mL | 3 mg/mL |
| S4697 | Saxagliptin hydrate | 1 mg/mL | 66 mg/mL | 66 mg/mL |
| S4636 | Teneligliptin hydrobromide | 100 mg/mL | 100 mg/mL | 17 mg/mL |
- DPP-4阻害剤(11)
- 新DPP-4製品
| 製品コード | 製品説明 | 文献中の使用例 | お客様のフィードバック |
|---|---|---|---|
| S4002 |
Sitagliptin phosphate monohydrateSitagliptin phosphate monohydrate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts. |
AR staining of non-CAVD and CAVD patient hVICs in the presence or absence of Sitagliptin (100 μM) after 4 weeks of osteogenic stimulation. The bar graph presents the AR-positive area measured in each culture dish.
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| S3031 |
LinagliptinLinagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8, and DPP-9. |
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| S3033 |
Vildagliptin (LAF-237)Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM. |
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| S1540 |
SaxagliptinSaxagliptin is a selective and reversible DPP4 inhibitor with IC50 of 26 nM. |
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| S2868 |
Alogliptin（SYK-322）benzoateAlogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. |
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| S5079新 |
Sitagliptin |
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| S5063新 |
Trelagliptin succinate |
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| S8565新 |
Omarigliptin (MK-3102)Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5). |
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| S7513 |
TrelagliptinTrelagliptin is a highly selective, long-acting DPP-4 inhibitor. Phase 3. |
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| S4697 |
Saxagliptin hydrateSaxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM. |
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| S4636 |
Teneligliptin hydrobromideTeneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM. |
