Glutaminase

Glutaminase製品

  • All (11)
  • Glutaminase阻害剤 (7)
  • Glutaminase拮抗剤(4)
  • 新製品
製品コード 製品名称 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7655 Telaglenastat (CB-839) CB-839 (Telaglenastat) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. Phase 1.
Signal Transduct Target Ther, 2023, 8(1):159
Cancer Discov, 2023, 13(7):1696-1719
J Thorac Oncol, 2023, S1556-0864(23)00197-1
S7753 BPTES BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. It has no effect on glutamate dehydrogenase activity and causes only a very slight inhibition of γ-glutamyl transpeptidase activity.
Gastroenterology, 2024, S0016-5085(24)00062-3
Cancer Commun (Lond), 2023, 43(8):909-937
Cell Rep Med, 2023, 4(5):101026
S8620 6-Diazo-5-oxo-L-norleucine 6-Diazo-5-oxo-L-norleucine (Diazooxonorleucine, L-6-Diazo-5-oxonorleucine, DON), an antibiotic isolated from Streptomyces, is a glutaminase antagonist with IC50 of ~1  mM for cKGA (kidney-type glutaminase). 6-Diazo-5-oxo-L-norleucine exhibits analgesic, antibacterial, antiviral and anticancer properties.
iScience, 2023, 26(10):107790
Cancer Cell, 2022, 40(10):1207-1222.e10
Biomolecules, 2022, 12(5)728
S8891 JHU-083 JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Solutions are unstable and should be fresh-prepared.
iScience, 2023, 26(10):107790
S6417 GK921 GK921 is a transglutaminase 2 (TGase 2) inhibitor with an IC50 of 8.93 μM under a modified assay condition.
J Immunol Res, 2021, 2021:4754454
S8892 JHU395 JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and significantly inhibits tumor growth without observed toxicity.
S8778 UPGL00004 UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2.
S8998 IACS-6274 IACS-6274 (IPN60090), is a potent, selective and orally active glutaminase inhibitor with potential antineoplastic and immunostimulating activities.
E2365 Glutaminase C-IN-1 Glutaminase C-IN-1 is an allosteric inhibitor of Glutaminase C (GAC) that inhibits cancer cell growth without affecting their normal cellular counterparts.
E1203New Sirpiglenastat Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. It has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response with immunomodulatory and antineoplastic activities.
E0134 L-Albizziin L-albizziin (L-alpha-amino-beta-ureidopropionic acid) is a potent inhibitor of glutamase. L-albizziin interferes with the utilisation of L-glutamine by the Debaryomyces spp. enzyme probably in a competitive and reversible manner since L-albizziin is also a substrate of the enzyme.
S7655 Telaglenastat (CB-839) CB-839 (Telaglenastat) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. Phase 1.
Signal Transduct Target Ther, 2023, 8(1):159
Cancer Discov, 2023, 13(7):1696-1719
J Thorac Oncol, 2023, S1556-0864(23)00197-1
S7753 BPTES BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. It has no effect on glutamate dehydrogenase activity and causes only a very slight inhibition of γ-glutamyl transpeptidase activity.
Gastroenterology, 2024, S0016-5085(24)00062-3
Cancer Commun (Lond), 2023, 43(8):909-937
Cell Rep Med, 2023, 4(5):101026
S6417 GK921 GK921 is a transglutaminase 2 (TGase 2) inhibitor with an IC50 of 8.93 μM under a modified assay condition.
J Immunol Res, 2021, 2021:4754454
S8778 UPGL00004 UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2.
S8998 IACS-6274 IACS-6274 (IPN60090), is a potent, selective and orally active glutaminase inhibitor with potential antineoplastic and immunostimulating activities.
E2365 Glutaminase C-IN-1 Glutaminase C-IN-1 is an allosteric inhibitor of Glutaminase C (GAC) that inhibits cancer cell growth without affecting their normal cellular counterparts.
E0134 L-Albizziin L-albizziin (L-alpha-amino-beta-ureidopropionic acid) is a potent inhibitor of glutamase. L-albizziin interferes with the utilisation of L-glutamine by the Debaryomyces spp. enzyme probably in a competitive and reversible manner since L-albizziin is also a substrate of the enzyme.
S8620 6-Diazo-5-oxo-L-norleucine 6-Diazo-5-oxo-L-norleucine (Diazooxonorleucine, L-6-Diazo-5-oxonorleucine, DON), an antibiotic isolated from Streptomyces, is a glutaminase antagonist with IC50 of ~1  mM for cKGA (kidney-type glutaminase). 6-Diazo-5-oxo-L-norleucine exhibits analgesic, antibacterial, antiviral and anticancer properties.
iScience, 2023, 26(10):107790
Cancer Cell, 2022, 40(10):1207-1222.e10
Biomolecules, 2022, 12(5)728
S8891 JHU-083 JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Solutions are unstable and should be fresh-prepared.
iScience, 2023, 26(10):107790
S8892 JHU395 JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and significantly inhibits tumor growth without observed toxicity.
E1203New Sirpiglenastat Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. It has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response with immunomodulatory and antineoplastic activities.
E1203New Sirpiglenastat Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. It has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response with immunomodulatory and antineoplastic activities.

Glutaminase阻害剤の選択性比較

Tags: Glutaminase inhibitor|Glutaminase agonist|Glutaminase activator|Glutaminase inducer|Glutaminase antagonist|Glutaminase signaling pathway|Glutaminase assay kit