PKM

亜型選択性的な製品

PKM製品

All (8)
PKM阻害剤 (3)
PKM活性剤(5)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S8279	Shikonin	Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.	J Pharm Anal, 2023, 13(2):187-200 Cancer Sci, 2023, 114(3):806-821 Cancers (Basel), 2023, 15(17)4356
S8616	PKM2 inhibitor(compound 3k)	PKM2 inhibitor(Compound 3K, PKM2-IN-1) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.	Nat Commun, 2023, 14(1):2157 J Exp Clin Cancer Res, 2023, 42(1):1 Brain Res, 2023, 1807:148321
S7928	DASA-58	DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.	Int J Biol Sci, 2022, 18(16):6210-6225 Int J Mol Sci, 2022, 23(2)775 Cell Biol Int, 2022, 10.1002/cbin.11780
S7302	TEPP-46 (ML265)	TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.	Cell Prolif, 2024, 57(2):e13548 J Clin Invest, 2023, 133(7)e166031 Mol Cell, 2022, S1097-2765(22)00541-X
S6508	Mitapivat	Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.	Proc Natl Acad Sci U S A, 2022, 119(40):e2210779119
E1328^New	TP-1454	TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells.
E2829	Alkannin	Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2), without inhibiting PKM1 and pyruvate kinase-L (PKL).
S5545	DL-Serine	Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
S8279	Shikonin	Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.	J Pharm Anal, 2023, 13(2):187-200 Cancer Sci, 2023, 114(3):806-821 Cancers (Basel), 2023, 15(17)4356
S8616	PKM2 inhibitor(compound 3k)	PKM2 inhibitor(Compound 3K, PKM2-IN-1) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.	Nat Commun, 2023, 14(1):2157 J Exp Clin Cancer Res, 2023, 42(1):1 Brain Res, 2023, 1807:148321
E2829	Alkannin	Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2), without inhibiting PKM1 and pyruvate kinase-L (PKL).
S7928	DASA-58	DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.	Int J Biol Sci, 2022, 18(16):6210-6225 Int J Mol Sci, 2022, 23(2)775 Cell Biol Int, 2022, 10.1002/cbin.11780
S7302	TEPP-46 (ML265)	TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.	Cell Prolif, 2024, 57(2):e13548 J Clin Invest, 2023, 133(7)e166031 Mol Cell, 2022, S1097-2765(22)00541-X
S6508	Mitapivat	Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.	Proc Natl Acad Sci U S A, 2022, 119(40):e2210779119
E1328^New	TP-1454	TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells.
S5545	DL-Serine	Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
E1328^New	TP-1454	TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells.

PKM阻害剤の選択性比較

Tags: PKM activator | PKM inhibitor | PKM modulator |PKM activity