2,4-Diamino-6-hydroxypyrimidine

製品コードS3688 バッチS368801

印刷

化学情報

Synonyms

DAHP

Storage
(From the date of receipt)

3 years -20°C(in the dark) powder

化学式

C₄H₆N₄O

分子量

126.12

CAS No.

56-06-4

Solubility (25°C)*

体外

DMSO

25 mg/mL (198.22 mM)

Water

6 mg/mL (47.57 mM)

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Clear solution

5%DMSO 1 Corn oil

10.0mg/ml

Taking the 1 mL working solution as an example, add 50 μL of 200 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	2,4-Diamino-6-hydroxypyrimidine (DAHP) is a specific inhibitor for GTP cyclohydrolase I, the rate-limiting enzyme in de novo pterin synthesis.
in vitro	2,4-diamino-6-hydroxy-pyrimidine (DAHP), an inhibitor of GTP cyclohydrolase I, blocks the synthesis of tetrahydrobiopterin (BH4), which is a known cofactor of inducible nitric oxide synthase (iNOS). DAHP is shown to suppress the production of nitric oxide by cytokine-activated fibroblasts, smooth muscle cells or endothelial cells which could be attributed to its function as a cofactor antagonist. DAHP down-regulates the expression of iNOS protein and mRNA in a BH4-independent manner^[1].
in vivo	DAHP has no effect on brain serotonin levels, presumably due to poor brain penetration. DAHP causes a rapid decrease (T1/2 of less than 12 hr) in the BH4 levels in all tissues examined, except in the brain. The BH4 level returns to within the normal range less than 24 hr after cessation of the administration of DAHP, a finding which suggests that the BH4 level is in a dynamic steady state maintained by rapid local biosynthesis^[2].

プロトコル(参考用のみ)

動物実験	動物モデル	C57BL/6 mice
	投薬量	3 g/kg/day
	投与方法	oral

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Suppression of GCH1 Sensitizes Ovarian Cancer and Breast Cancer to PARP Inhibitor [ J Oncol, 2023, 2023:1453739]	PubMed: 36793373
EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer [ Cell Rep, 2022, 41(11):111827]	PubMed: 36516759

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。