4-Hydroxytamoxifen (Afimoxifene)

製品コードS7827 バッチS782701

印刷

化学情報

Chemical Structure Synonyms Afimoxifene Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C26H29NO2
分子量 387.51 CAS No. 68392-35-8
Solubility (25°C)* 体外 DMSO 77 mg/mL (198.7 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.
in vitro 4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes[1]. 4-HT activates on-target modification frequency for intein-Cas9 variants [3].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Adult Rat and Mouse Cardiac Myocytes
濃度 0, 0.5, 1, 3, 5, and 10 µM
反応時間 15-45 min
実験の流れ

For sarcomere length measurements, cells are covered in Tyrode’s containing 4OHT, allowed to reach 36 ± 1°C, and then stimulated at 0.2 Hz.
動物実験 動物モデル Sprague-Dawley rats
投薬量 21 mg/kg, 54 μmol/kg
投与方法 oral administration

カスタマーフィードバック

, , Oncogene, 2016, 36(16):2255-2264

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation [ Nat Commun, 2024, 15(1):2983] PubMed: 38582860
Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma [ Cell Rep Med, 2024, 5(3):101468] PubMed: 38508144
The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability [ Cell Rep, 2024, 43(2):113779] PubMed: 38358891
Macrophages Promote Subtype Conversion and Endocrine Resistance in Breast Cancer [ Cancers (Basel), 2024, 16(3)678] PubMed: 38339428
Novel Estrogen Receptor Dimerization BRET-Based Biosensors for Screening Estrogenic Endocrine-Disrupting Chemicals [ Biomater Res, 2024, 28:0010] PubMed: 38464469
Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A [ Nat Commun, 2023, 14(1):5400] PubMed: 37669939
Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A [ Nat Commun, 2023, 14(1):5400] PubMed: 37669939
AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer [ Autophagy, 2023, 21:1-16.] PubMed: 37733921
Liver X Receptor Inverse Agonist GAC0001E5 Impedes Glutaminolysis and Disrupts Redox Homeostasis in Breast Cancer Cells [ Biomolecules, 2023, 13(2)345] PubMed: 36830714
SRSF5 Regulates the Expression of BQ323636.1 to Modulate Tamoxifen Resistance in ER-Positive Breast Cancer [ Cancers (Basel), 2023, 15(8)2271] PubMed: 37190199

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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