受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | Afimoxifene | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
|
化学式 | C26H29NO2 |
|||
分子量 | 387.51 | CAS No. | 68392-35-8 | |
Solubility (25°C)* | 体外 | DMSO | 77 mg/mL (198.7 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | 4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. |
---|---|
in vitro | 4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes[1]. 4-HT activates on-target modification frequency for intein-Cas9 variants [3]. |
細胞アッセイ | 細胞株 | Adult Rat and Mouse Cardiac Myocytes |
---|---|---|
濃度 | 0, 0.5, 1, 3, 5, and 10 µM | |
反応時間 | 15-45 min | |
実験の流れ | For sarcomere length measurements, cells are covered in Tyrode’s containing 4OHT, allowed to reach 36 ± 1°C, and then stimulated at 0.2 Hz. |
|
動物実験 | 動物モデル | Sprague-Dawley rats |
投薬量 | 21 mg/kg, 54 μmol/kg | |
投与方法 | oral administration |
|
, , Oncogene, 2016, 36(16):2255-2264
The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation [ Nat Commun, 2024, 15(1):2983] | PubMed: 38582860 |
Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma [ Cell Rep Med, 2024, 5(3):101468] | PubMed: 38508144 |
The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability [ Cell Rep, 2024, 43(2):113779] | PubMed: 38358891 |
Macrophages Promote Subtype Conversion and Endocrine Resistance in Breast Cancer [ Cancers (Basel), 2024, 16(3)678] | PubMed: 38339428 |
Novel Estrogen Receptor Dimerization BRET-Based Biosensors for Screening Estrogenic Endocrine-Disrupting Chemicals [ Biomater Res, 2024, 28:0010] | PubMed: 38464469 |
Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A [ Nat Commun, 2023, 14(1):5400] | PubMed: 37669939 |
Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A [ Nat Commun, 2023, 14(1):5400] | PubMed: 37669939 |
AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer [ Autophagy, 2023, 21:1-16.] | PubMed: 37733921 |
Liver X Receptor Inverse Agonist GAC0001E5 Impedes Glutaminolysis and Disrupts Redox Homeostasis in Breast Cancer Cells [ Biomolecules, 2023, 13(2)345] | PubMed: 36830714 |
SRSF5 Regulates the Expression of BQ323636.1 to Modulate Tamoxifen Resistance in ER-Positive Breast Cancer [ Cancers (Basel), 2023, 15(8)2271] | PubMed: 37190199 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。