4-Methylbenzylidene camphor

製品コードS3704 バッチS370401

化学情報

	Synonyms	Enzacamene, 4-MBC	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₈H₂₂O
	分子量	254.37	CAS No.	36861-47-9
Solubility (25°C)*	体外	DMSO	50 mg/mL (196.56 mM)
		Ethanol	50 mg/mL (196.56 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	4-Methylbenzylidene camphor (Enzacamene, 4-MBC) is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation.
in vivo	Though 4MBC is weakly estrogenic in the reproductive system of fishes and rodents it shows strong anti-osteoporotic effects comparable to E2 after chronic application. 4MBC is resorbed through the skin after dermal administration resulting in identical biotransformation of this UV filter in humans and rats. 4MBC is a potent inhibitor of the pituitary-thyroid-axis^[1]. 4-MBC prevents bone loss and exerted a very weak estrogenic effect on the uterus and the vagina after a 3-month treatment of Ovx rats. 4-MBC exerts a positive effect on the mitochondria and microstructure of the skeletal muscle during the early stage of osteoporotic fracture healing^[2].

製品説明

4-Methylbenzylidene camphor (Enzacamene, 4-MBC) is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation.

in vivo

Though 4MBC is weakly estrogenic in the reproductive system of fishes and rodents it shows strong anti-osteoporotic effects comparable to E2 after chronic application. 4MBC is resorbed through the skin after dermal administration resulting in identical biotransformation of this UV filter in humans and rats. 4MBC is a potent inhibitor of the pituitary-thyroid-axis^[1]. 4-MBC prevents bone loss and exerted a very weak estrogenic effect on the uterus and the vagina after a 3-month treatment of Ovx rats. 4-MBC exerts a positive effect on the mitochondria and microstructure of the skeletal muscle during the early stage of osteoporotic fracture healing^[2].

プロトコル(参考用のみ)

動物実験	動物モデル	Sprague-Dawley rats
	投薬量	10, 33, 100, 333, 600mg/kg b.w./d
	投与方法	by oral gavage

参考

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。