受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | NSC-92523 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
|
化学式 | C11H12N2O3 |
|||
分子量 | 220.22 | CAS No. | 56-69-9 | |
Solubility (25°C)* | 体外 | DMSO | 44 mg/mL (199.8 mM) | |
Water | 7 mg/mL (31.78 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | 5-Hydroxytryptophan (5-HTP, NSC-92523), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor for the treatment of depression. |
---|---|
in vitro | 5-Hydroxytryptophan (5-HTP) is the intermediate metabolite of the essential amino acid L-tryptophan (LT) in the biosynthesis of serotonin. It easily crosses the blood-brain barrier and effectively increases central nervous system (CNS) synthesis of serotonin. Therapeutic administration of 5-HTP has been shown to be effective in treating a wide variety of conditions, including depression, fibromyalgia, binge eating associated with obesity, chronic headaches, and insomnia. [1] Clinical available evidence suggests 5-Hydroxytryptophan is better than placebo at alleviating depression. [2] |
in vivo | LD50: Mice 1800mg/kg (i.g.); Rats 300mg/kg (i.g.) [3] |
|
Role of 5-HT degradation in acute liver injury induced by carbon tetrachloride [ Eur J Pharmacol, 2021, 908:174355] | PubMed: 34280394 |
Relationship between fatigue caused by type 2 diabetes mellitus and 5-HT degradation in skeletal muscle [ Acta Pharmaceutica Sinica, 2021, (1): 190-200] | PubMed: None |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。