Acitretin

製品コードS1368 バッチS136804

化学情報

	Synonyms	Etretin, RO 10-1670	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₁H₂₆O₃
	分子量	326.43	CAS No.	55079-83-9
Solubility (25°C)*	体外	DMSO	65 mg/mL (199.12 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明	Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.
in vitro	Acitretin stimulates ADAM10 promoter activity with an EC(50) of 1.5 mM and leads to an increase of mature ADAM10 protein that results in a two- to three-fold increase of the ratio between alpha- and beta-secretase activity in neuroblastoma cells. ^[1] Acitretin (5-20 μM) impairs mitochondrial phosphorylation efficiency as demonstrated by the decrease in the state 3 respiration and ATP levels, and by the increase in the lag phase of ADP phosphorylation cycle, without affecting the membrane potential. Acitretin induces Ca(2+)-mediated mitochondrial permeability transition (MPT) and decreased the adenine nucleotide translocase (ANT) content. ^[2] Acitretin preferentially inhibits the growth of SCL-1 cells in a dose- and time-dependent manner, but not of non-malignant keratinocyte HaCaT cells. Acitretin increases the levels of CD95 (Fas), CD95-ligand and Fas-associated death domain. Acitretin is able to induce apoptosis in skin cancer cells possibly via death receptor CD95 apoptosis pathway without affecting the viability of normal keratinocyte. ^[3]
in vivo	Acitretin undergoes alpha-oxidation, chain shortening O-demethylation, and glucuronidation in the perfused rat liver. ^[4] Acitretin rapidly appears in liver and muscle of rats, where it undergoes redistribution into skin and adipose tissue. ^[5]

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カスタマーフィードバック

: Data from [Data independently produced by , , Antimicrob Agents Chemother, 2016, 61(11). pii: e01368-17]

: Data from [Data independently produced by , , Saudi Pharm J, 2017, 25(4):620-624]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Isolation of Reporter Cells That Respond to Vitamin A and/or D Using a piggyBac Transposon Promoter-Trapping Vector System [ Int J Mol Sci, 2022, 23(16)9366]	PubMed: 36012634
Evaluation of the Innate Immune Modulator Acitretin as a Strategy To Clear the HIV Reservoir. [Garcia-Vidal E, et al. Antimicrob Agents Chemother, 2017, 61(11). pii: e01368-17]	PubMed: 28874382
Acitretin modulates HaCaT cells proliferation through STAT1- and STAT3-dependent signaling. [Qin X, et al. Saudi Pharm J, 2017, 25(4):620-624]	PubMed: 28579901

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。