Anastrozole

製品コードS1188 バッチS118802

印刷

化学情報

Chemical Structure Synonyms ZD-1033 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C17H19N5
分子量 293.37 CAS No. 120511-73-1
Solubility (25°C)* 体外 DMSO 59 mg/mL (201.11 mM)
Ethanol 59 mg/mL (201.11 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Anastrozole is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids.
in vitro Anastrozole has high intrinsic potency in vitro and inhibits human placental aromatase with an IC50 of 15 nM. Anastrozole it is 200 times as potent as AG, twice as potent as 4-OHA and one third as potent as fadrozole. [1]. Anastrozole inhibits aromatase by binding competitively to the hem group of the CYP unit of the enzyme thereby reducing estrogen biosynthesis in the periphery and the breast. Anastrozole has little or no effect on other steroid hormones. [2]
in vivo Anastrozole (0.1 mg/kg) given orally to mature rats on Day 2 or 3 of the estrous cycle, blocked ovulation in mature females; in pubertal rats, the same dose given for 3 days completely blocks androstenedione-stimulated uterine development. These effects may be attributes to inhibition of the normal preovulatory rise in ovarian follicular estrogen synthesis in mature females and to inhibition of metabolism of the exogenous androstenedione by the immature ovary in prepubertal females. Twice-daily administration of >9.1 mg/kg of Anastrozole given orally to male pigtailed monkeys inhibits peripheral aromatase, thereby reducing circulating estradiol concentrations by 50% to 60%. [2]

プロトコル(参考用のみ)

カスタマーフィードバック

Data from [Data independently produced by , , Oncotarget, 2016, 7(34):54157-54173]

Data from [Data independently produced by , , Int J Oncol, 2015, 46(4):1481-90. ]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

CDK4/6 inhibitors induce breast cancer senescence with enhanced anti-tumor immunogenic properties compared with DNA-damaging agents [ Mol Oncol, 2023, 10.1002/1878-0261.13541] PubMed: 37854019
SERPINA3-ANKRD11-HDAC3 pathway induced aromatase inhibitor resistance in breast cancer can be reversed by HDAC3 inhibition [ Commun Biol, 2023, 6(1):695] PubMed: 37414914
Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis [ Cell Discov, 2022, 8(1):40] PubMed: 35504898
CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis [ Nat Commun, 2022, 13(1):4995] PubMed: 36008411
Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH) [ Nat Commun, 2022, 13(1):4549] PubMed: 35927268
SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagy [ J Med Virol, 2022, 94(11):5174-5188] PubMed: 35765167
Pantothenate Kinase 1 Inhibits the Progression of Hepatocellular Carcinoma by Negatively Regulating Wnt/β-catenin Signaling [ Int J Biol Sci, 2022, 18(4):1539-1554] PubMed: 35280671
STING controls energy stress-induced autophagy and energy metabolism via STX17 [ J Cell Biol, 2022, 221(7)e202202060] PubMed: 35510944
Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation [ iScience, 2022, 25(7):104544] PubMed: 35747386
Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei [ J Pers Med, 2022, 12(2)258] PubMed: 35207746

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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