Fluoxetine HCl

製品コードS1333 バッチS133306

化学情報

	Synonyms	Lilly 110140 HCl, LY-110140 HCl	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₇H₁₈F₃NO.HCl
	分子量	345.79	CAS No.	56296-78-7
Solubility (25°C)*	体外	DMSO	69 mg/mL (199.54 mM)
		Ethanol	9 mg/mL (26.02 mM)
		Water	6 mg/mL (17.35 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Fluoxetine HCl (LY-110140) is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.
in vitro	Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. ^[1] Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. ^[2] Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. ^[3] Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration. ^[4]
in vivo	Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague–Dawley rats. ^[1] Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone. ^[5]

製品説明

Fluoxetine HCl (LY-110140) is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.

in vitro

Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. ^[1]

Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. ^[2]

Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. ^[3]

Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration. ^[4]

in vivo

Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague–Dawley rats. ^[1]

Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone. ^[5]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	MDA-MB-231 cells
	濃度	1 µM
	反応時間	24 h
	実験の流れ	Cells were treated with indicated concentrations of drug for 24 h.
動物実験	動物モデル	Male Sprague-Dawley rats
	投薬量	10 mg/kg
	投与方法	s.c.

参考

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カスタマーフィードバック

: , , G3 (Bethesda), 2014, 4(6):1081-9.

: Data from [Data independently produced by , , J Neuroinflammation, 2017, 14(1):186]

: Data from [Data independently produced by , , Brain Res Bull, 2017, 130:146-155]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

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Liquiritin Alleviates Depression-Like Behavior in CUMS Mice by Inhibiting Oxidative Stress and NLRP3 Inflammasome in Hippocampus [ Evid Based Complement Alternat Med, 2022, 2022:7558825]	PubMed: 35069768
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Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines [ Sci Rep, 2021, 11(1):1250]	PubMed: 33441923
Potential impacts of diabetes mellitus and anti-diabetes agents on expressions of sodium-glucose transporters (SGLTs) in mice [ Endocrine, 2021, 10.1007/s12020-021-02818-7]	PubMed: 34255273

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人間や獣医の診断であるか治療的な使用のためにでない。

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