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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C42H62O16 |
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分子量 | 822.93 | CAS No. | 1405-86-3 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (121.51 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO). |
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in vitro | Glycyrrhizin inhibits monoamine oxidase (MAO) with the IC50 value of 0.16 μM[4]. |
in vivo | Glycyrrhizin increases the levels of monoamines like epinephrine and dopamine in brains of mice[3]. |
細胞アッセイ | 細胞株 | Cell-free assays |
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濃度 | 0.16 μM | |
反応時間 | ||
実験の流れ | ||
動物実験 | 動物モデル | Swiss albino mice |
投薬量 | 1.5, 3.0 and 6.0 mg/kg | |
投与方法 | i.p. |
Data from [Data independently produced by , , DNA Cell Biol, 2017, 36(1):67-76]
Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis [ Ecotoxicol Environ Saf, 2024, 272:116068] | PubMed: 38330871 |
The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization [ Front Immunol, 2023, 14:1024706] | PubMed: 36761729 |
The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization [ Front Immunol, 2023, 10.3389/fimmu.2023.1024706] | PubMed: 36761729 |
Glycyrrhizin mitigates acute lung injury by inhibiting the NLRP3 inflammasome in vitro and in vivo [ J Ethnopharmacol, 2023, 303:115948] | PubMed: 36423713 |
Connexin43 is associated with the progression of clear cell renal carcinoma and is regulated by tangeretin to sygergize with tyrosine kinase inhibitors [ Transl Oncol, 2023, 35:101712] | PubMed: 37354638 |
Effects of HMGB1/RAGE/cathespin B inhibitors on alleviating hippocampal injury by regulating microglial pyroptosis and caspase activation in neonatal hypoxic-ischemic brain damage [ J Neurochem, 2023, 167(3):410-426] | PubMed: 37753942 |
Glycyrrhizin Attenuates Hypoxic-Ischemic Brain Damage by Inhibiting Ferroptosis and Neuroinflammation in Neonatal Rats via the HMGB1/GPX4 Pathway [ Oxid Med Cell Longev, 2022, 2022:8438528] | PubMed: 35432719 |
Inhibition of HMGB1/TLR4 Signaling Pathway by Digitoflavone: A Potential Therapeutic Role in Alcohol-Associated Liver Disease [ J Agric Food Chem, 2022, 70(9):2968-2983] | PubMed: 35212223 |
Glycyrrhizin alleviates sepsis-induced acute respiratory distress syndrome via suppressing of HMGB1/TLR9 pathways and neutrophils extracellular traps formation [ Int Immunopharmacol, 2022, 108:108730] | PubMed: 35354111 |
HMGB1 mediates cognitive impairment caused by the NLRP3 inflammasome in the late stage of traumatic brain injury [ J Neuroinflammation, 2021, 18(1):241] | PubMed: 34666797 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。