|
受注：045-509-1970 |
技術サポート：[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
化学情報
|
Synonyms | NSC 293100 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
| 化学式 | C18H18O2 |
|||
| 分子量 | 266.334 | CAS No. | 35354-74-6 | |
| Solubility (25°C)* | 体外 | DMSO | 53 mg/mL (198.99 mM) | |
| Water | 53 mg/mL (198.99 mM) | |||
| Ethanol | Insoluble | |||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
||||
溶剤液（一定の濃度）を調合する
生物活性
| 製品説明 | Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Honokiol causes G0/G1 phase arrest, induces apoptosis, and autophagy via the ROS/ERK1/2 signaling pathway. Honokiol inhibits hepatitis C virus (HCV) infection. Phase 3. |
|---|---|
| in vitro | Honokiol shows pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Honokiol is effective on inducing apoptosis in SVR angiosarcoma cells. Treatment of SVR cells with honokiol causes decreased phosphorylation of MAP kinase, akt, and c-src. In addition, honokiol potentiates TRAIL-mediated apoptosis, and honokiol cytotoxicity is partially abrogated by neutralizing antibodies to TRAIL. Honokiol also has direct antiangiogenic activity, in that honokiol blocks the phosphorylation and rac activation due to VEGF-VEGFR2 interactions. [1] Honokiol causes apoptosis in CLL cells through activation of caspase 8, followed by caspase 9 and 3 activation. Honokiol prevents interleukin-4-mediated survival of CLL cells, and potentiats the cytotoxicity of chlorambucil, fludarabine, and cladribine. [3] Honokiol kills myeloma cells from relapsed patients at doses that does not kill PBMCs. Caspase 3, 7, 8, and 9 are induced by honokiol treatment, as well as PARP cleavage. [2] Honokiol is found to induce apoptosis in the colon cancer cell lines RKO. [4] Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. [5] Honokiol may act as a potent anti-inflammatory agent with multipotential activities due to an inhibitory effect on the PI3K/Akt pathway. [6] |
| in vivo | Honokiol is highly effective against SVR angiosarcoma in nude mice. [1] Honokiol inhibits the growth of RKO cells in murine xenografts. [4] Honokiol prevents the growth of MDA-MD-231 breast cancer cells in murine xenografts. [7] |
プロトコル(参考用のみ)
参考
カスタマーフィードバック
-
, , Front Pharmacol, 2017, 8:199
-
Data from [Data independently produced by , , Front Pharmacol, 2018, 9:558]
Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：
| Antioxidant Nanoparticles Restore Cisplatin-Induced Male Fertility Defects by Promoting MDC1-53bp1-Associated Non-Homologous DNA Repair Mechanism and Sperm Intracellular Calcium Influx [ Int J Nanomedicine, 2023, 18:4313-4327] | PubMed: 37576465 |
| Functional restoration of lysosomes and mitochondria through modulation of AKT activity ameliorates senescence [ Exp Gerontol, 2023, 173:112091] | PubMed: 36657533 |
| Sirt3 mediates the benefits of exercise on bone in aged mice [ Cell Death Differ, 2022, 10.1038/s41418-022-01053-5] | PubMed: 36153410 |
| Honokiol ameliorates cisplatin-induced acute kidney injury via inhibition of mitochondrial fission [ Br J Pharmacol, 2022, 10.1111/bph.15837] | PubMed: 35297042 |
| Magnesium Isoglycyrrhizinate Reduces the Target-Binding Amount of Cisplatin to Mitochondrial DNA and Renal Injury through SIRT3 [ Int J Mol Sci, 2022, 23(21)13093] | PubMed: 36361883 |
| Upregulation of LINC01426 promotes the progression and stemness in lung adenocarcinoma by enhancing the level of SHH protein to activate the hedgehog pathway [ Cell Death Dis, 2021, 12(2):173] | PubMed: 33568633 |
| Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis [ Cell Death Dis, 2021, 12(9):847] | PubMed: 34518519 |
| SINO Syndrome Causative KIDINS220/ARMS Gene Regulates Adipocyte Differentiation [ Front Cell Dev Biol, 2021, 9:619475] | PubMed: 33763417 |
| Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity [ Am J Cancer Res, 2021, 11(6):3039-3054] | PubMed: 34249443 |
| A combination therapy using mTOR inhibitor and Honokiol effectively induces autophagy through the modulation of AXL and Rubicon in renal cancer cells, and restricts renal tumor growth following an organ transplantation [ Carcinogenesis, 2021, bgab126] | PubMed: 34965300 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。