Isoliquiritigenin

製品コードS2404 バッチS240402

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C15H12O4
分子量 256.25 CAS No. 961-29-5
Solubility (25°C)* 体外 Ethanol 26 mg/mL (101.46 mM)
DMSO 12 mg/mL (46.82 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.
in vitro Isoliquiritigenin may be effective in preventing diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. [1] Isoliquiritigenin may also serve as a skin-lightening agent by inhibiting mono- and diphenolase tyrosinase activities with an IC50 of 8.1 μM. [2] Isoliquiritigenin induces cell cycle arrest and cell growth inhibition in DU145 and LNCaP prostate cancer cell lines. [3] Isoliquiritigenin induces apoptosis of human gastric cancer MGC-803 cells through increasing the intracellular free calcium concentration and decreasing the mitochondrial transmembrane potential (Deltapsi(m)). [4]
in vivo LD50: Mice >6g/kg (i.g.) [5]

プロトコル(参考用のみ)

カスタマーフィードバック

Data from [Data independently produced by J Biol Chem, 2014, 289(52), 35839-48]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

High-Throughput Drug Library Screening in Primary KMT2A-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling [ Biomedicines, 2022, 10(3)638] PubMed: 35327440
Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer [ Cancer Res, 2021, 81(16):4257-4274] PubMed: 34185677
Isoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest. [ Biomed Res Int, 2020, 2020:9259852] PubMed: 32190688
Integrating Differential Gene Expression Analysis with Perturbagen-Response Signatures May Identify Novel Therapies for Thyroid-Associated Orbitopathy [ Transl Vis Sci Technol, 2020, 9(9):39] PubMed: 32908802
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis. [ Int J Biol Sci, 2019, 15(11):2497-2508] PubMed: 31595166
Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3. [ Proc Natl Acad Sci U S A, 2018, 115(42):E9869-E9878] PubMed: 30275324
Cell-based assay system for high-throughput screening of anti-photo-aging agents in fibroblast transfectants. [Lee S, et al. Cytotechnology, 2016, 68(4):1633-40] PubMed: 26281901
Isoliquiritigenin Induces Apoptosis and Inhibits Xenograft Tumor Growth of Human Lung Cancer Cells by Targeting Both Wildtype and L858R/T790M Mutant EGFR. [Jung SK, et al. J Biol Chem, 2014, 10.1074/jbc.M114.585513] PubMed: 25368326

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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