Levonorgestrel

製品コードS1727 バッチS172703

印刷

化学情報

Chemical Structure Synonyms D-Norgestrel Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C21H28O2
分子量 312.45 CAS No. 797-63-7
Solubility (25°C)* 体外 DMSO 62 mg/mL (198.43 mM)
Ethanol 4 mg/mL (12.8 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.
in vitro Levonorgestrel suppresses the stimulation of progesterone secretion induced by oLH, dibutyryl-cAMP and Pregnenolone in rats luteal cells. [1] Levonorgestrel also inhibits constrictions evoked by either a high potassium (K(+)) solution or phorbol myristate acetate (PMA) in the absence and presence of extracellular calcium (Ca(2+)). Levonorgestrel depresses contractions evoked by Ca(2+) and reduces (45)Ca(2+) influx in depolarized veins. Levonorgestrel increases levels of cyclic AMP and inhibits PMA-induced activation of protein kinase C in veins. Levonorgestrel causes endothelium-independent relaxations of jugular veins via inhibition of Ca(2+) entry and of protein kinase Cactivation. [2] Levonorgestrel inhibition of both estrogen-induced pituitary weight increment and hyperprolactinemia is reduced by mifepristone, whereas Flutamide is unable to block Levonorgestrel effects [3]
in vivo Levonorgestrel down-regulates the mRNA expression of follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) β and progesterone receptor (PR) in the ovary, and ERα and PR in the uterus of Mongolian gerbils. [4] Levonorgestrel causes a significant upregulation of the mRNA expression of the gene encoding luteinising hormone β-subunit (lhβ) and the suppression of the mRNA expression of the gene encoding follicle-stimulating hormone β-subunit (fshβ) in the pituitary of both male and female roach. Levonorgestrel disrupts the reproductive system of pubertalroach by affecting the pituitary gonadotropin expression and the sex steroid levels in pubertal roach (Rutilus rutilus). [5]

プロトコル(参考用のみ)

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Reservoir-Style Polymeric Drug Delivery Systems: Empirical and Predictive Models for Implant Design [ Pharmaceuticals -Basel, 2022, 15-101226] PubMed: 36297338
Long-acting biodegradable implant for sustained delivery of antiretroviral (ARV) and hormones [ J Control Release, 2021, S0168-3659(21)00550-2] PubMed: 34678316
Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling [ Nat Cancer, 2020, 1(2):235-248] PubMed: 32613204

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。