Magnolol

製品コードS2321 バッチS232102

印刷

化学情報

Chemical Structure Synonyms NSC 293099 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C18H18O2
分子量 266.33 CAS No. 528-43-8
Solubility (25°C)* 体外 DMSO 53 mg/mL (199.0 mM)
Ethanol 53 mg/mL (199.0 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Clear solution
5% DMSO 95% Corn oil
0.3mg/ml Taking the 1 mL working solution as an example, add 50 μL of 6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
2.65mg/ml Taking the 1 mL working solution as an example, add 50 μL of 53 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-κB activation.
in vitro

Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. [1] Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml. [2]
in vivo

LD50: Mice 2200mg/kg (i.g.). [3]

プロトコル(参考用のみ)

カスタマーフィードバック

Data from [Data independently produced by , , Inflamm Res, 2016, 65(1):81-93]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

FGF7/FGFR2-JunB signalling counteracts the effect of progesterone in luminal breast cancer [ Mol Oncol, 2022, 16(15):2823-2842] PubMed: 35726195
Magnolol limits NFκB-dependent inflammation by targeting PPARγ relieving retinal ischemia/reperfusion injury [ Int Immunopharmacol, 2022, 112:109242] PubMed: 36152538
Maternal magnolol supplementation alters placental morphology, promotes placental angiogenesis during mid-gestation and improves offspring growth in a pregnant mouse model [ Reprod Biol, 2021, 21(4):100567] PubMed: 34653815
Upregulation of HIF1-α via an NF-κB/COX2 pathway confers proliferative dominance of HER2-negative ductal carcinoma in situ cells in response to inflammatory stimuli [ Neoplasia, 2020, 22(11):576-589] PubMed: 32980776
Thin-layer chromatographic quantification of magnolol and honokiol in dietary supplements and selected biological properties of these preparations [ J Chromatogr A, 2020, 1625:461230] PubMed: 32709311
Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator [Li Z Micromachines, 2018, 9(6)] PubMed: 30424207
Anti-angiogenic and anti-inflammatory effect of Magnolol in the oxygen-induced retinopathy model. [Yang B, et al. Inflamm Res, 2016, 65(1):81-93] PubMed: 26547789

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。