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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C48H80O13 |
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分子量 | 889.1 | CAS No. | 65101-87-3 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (112.47 mM) | |
Ethanol | 100 mg/mL (112.47 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Nanchangmycin is a polyether antibiotic with similar structure to dianemycin and is very active against a broad spectrum of harmful nematodes and insects but not for mammals and plants. |
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in vitro | Nanchangmycin inhibits gram-positive bacteria. [1] |
in vivo | Nanchangmycin can be used as a growth promotant in poultry and to cure coccidiosis in chickens[1]. Nanchangmycin is a bacterially-derived natural product that potently blocked ZIKV infection across diverse cell types. It blocks ZIKV entry, as well as DENV infection[2]. |
特徴 | Polyether antibiotic produced by Streptomyces nanchangensis NS3226. |
細胞アッセイ | 細胞株 | U2OS |
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濃度 | 0.7 μM | |
反応時間 | 1 h | |
実験の流れ | 5000 cells were plated in 25ul media per well in 384-well plates. The next day, 50 nl of drugs were transfered to each well for a final concentration of 0.7uM/0.2% DMSO in U2OS. The drug treated U2OS cells were infected with Zika MR766, MOI=0.125 and fixed at 48 hours post infection (hpi). |
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Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells [ Elife, 2022, 11e74513] | PubMed: 35617485 |
Identification of Estrogen Receptor Modulators as Inhibitors of Flavivirus Infection [ Antimicrob Agents Chemother, 2020, 1;AAC.00289-20] | PubMed: 32482672 |
Epithelial to mesenchymal transition is mediated by both TGF-β canonical and non-canonical signaling during axolotl limb regeneration [ Sci Rep, 2019, 9(1):1144] | PubMed: 30718780 |
Genome-Wide Mutagenesis of Dengue Virus Reveals Plasticity of the NS1 Protein and Enables Generation of Infectious Tagged Reporter Viruses. [ J Virol, 2017, 91(23)] | PubMed: 28956770 |
Development and validation of a multi-residue screening method for veterinary drugs, their metabolites and pesticides in meat using liquid chromatography-tandem mass spectrometry [Wei H Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2015, 32(5):686-701] | PubMed: 25632989 |
Development and validation of a multi-residue screening method for veterinary drugs, their metabolites and pesticide in meat using liquid chromatography - tandem mass spectrometry. [Wei H, et al. Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2015, 10.1080/19440049.2015.1008588] | PubMed: 25632989 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。