Natamycin

製品コードS1517 バッチS151707

印刷

化学情報

Chemical Structure Synonyms Pimaricin Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C33H47NO13
分子量 665.73 CAS No. 7681-93-8
Solubility (25°C)* 体外 DMSO 10 mg/mL (15.02 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Natamycin (Pimaricin), a natural and versatile anti-fungal agent during fermentation by the bacterium Streptomyces natalensis, commonly found in soil; with little to no flavour interference
in vitro Natamycin binds specifically to ergosterol present in model membranes. Natamycin does not change the permeability of the yeast plasma membrane under conditions that growth is blocked. [1] Natamycin blocks the fusion of isolated vacuoles without compromising the barrier function of the vacuolar membrane. Natamycin perturbs the cellular vacuole morphology, causing the formation of many more small vacuolar structures in yeast cells. Natamycin inhibits the priming stage of vacuole fusion. [2] Natamycin shows low MIC against the dematiaceous fungi, Curvularia species. [3] Natamycin is complexed with gamma-cyclodextrin (NT-gamma CyD) to increase the solubility and stability of NT in aqueous solutions and reduce the side effects of the drug without decreasing antimycotic activity. [4] MIC90 of Natamycin alone and Natamycin-gamma CyD complexes are below 0.0313 mg/mL, suggesting that complexation with gamma CyD has effectively increased the antimycotic activity of Natamycin, thus indicating the clinical usefulness of Natamycin-gamma CyD complexes. [5]

プロトコル(参考用のみ)

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Reduced administration frequency for the treatment of fungal keratitis: a sustained natamycin release from a micellar solution. [ Expert Opin Drug Deliv, 2020, 17(3):407-421] PubMed: 32009483
The combined utilization of Chlorhexidine and Voriconazole or Natamycin to combat Fusarium infections [ BMC Microbiol, 2020, 20(1):275] PubMed: 32891143

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。