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Synonyms | NSC 76751, Hexamethoxyflavone | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C21H22O8 |
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分子量 | 402.39 | CAS No. | 478-01-3 | |
Solubility (25°C)* | 体外 | DMSO | 80 mg/mL (198.81 mM) | |
Ethanol | 5 mg/mL (12.42 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. |
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in vitro | Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. Nobiletin, a polymethoxyflavonoid, is identified as an inhibitor of both NO and O 2- generation. Nobiletin significantly inhibites two skin inflammation induced by double TPA application. It also suppresses the expression of cyclooxygenase-2 and inducible NO synthase proteins and prostaglandin E2 release. [1] Nobiletin inhibites the tumor-invasive activity of human fibrosarcoma HT-1080 cells in the Matrigel model, not only by suppressing the expression of MMPs but also augmenting TIMP-1 production through interfering the phosphatidylinositol 3-kinase pathway (PI3-K). [2] Nobiletin may also prevent atherosclerosis at the level of the vascular wall by inhibiting macrophage foam-cell formation. [3] |
in vivo | LD50: 780mg/kg (i.g.). [4] |
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, , Nutr Metab (Lond), 2015, 12:23.
Flavonoids regulate LDLR through different mechanisms tied to their specific structures [ J Lipid Res, 2024, S0022-2275(24)00044-0] | PubMed: 38556050 |
The Circadian Nobiletin-ROR Axis Suppresses Adipogenic Differentiation and IκBα/NF-κB Signaling in Adipocytes [ Nutrients, 2023, 15(18)3919] | PubMed: 37764703 |
Nobiletin, a NF-κB signaling antagonist, promotes BMP-induced bone formation [ FASEB Bioadv, 2023, 5(2):62-70] | PubMed: 36816515 |
ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer [ Cell Death Dis, 2022, 13(4):374] | PubMed: 35440077 |
The clock modulator Nobiletin mitigates astrogliosis-associated neuroinflammation and disease hallmarks in an Alzheimer's disease model [ FASEB J, 2022, 36(3):e22186] | PubMed: 35120261 |
Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial dysfunction [ J Nutr Biochem, 2021, S0955-2863(21)00308-9] | PubMed: 34695558 |
Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma [ Cancer Biol Med, 2021, 18(1):227-244] | PubMed: 33628597 |
Cardiolipin Synthesis in Skeletal Muscle Is Rhythmic and Modifiable by Age and Diet [ Oxid Med Cell Longev, 2020, 2020:5304768] | PubMed: 32617138 |
Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors [ Int J Mol Sci, 2020, 21(14):5025] | PubMed: 32708687 |
Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge. [ Nat Commun, 2019, 10(1):3923] | PubMed: 31462679 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。