Oridonin

製品コードS2335 バッチS233504

印刷

化学情報

Chemical Structure Synonyms NSC-250682, Isodonol, Rubescenin Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C20H28O6
分子量 364.43 CAS No. 28957-04-2
Solubility (25°C)* 体外 DMSO 72 mg/mL (197.56 mM)
Ethanol 34 mg/mL (93.29 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Oridonin, a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibits AKT1 and AKT2 kinase activity with IC50 of 8.4 μM and 8.9 μM, respectively.
in vitro

Oridonin effectively inhibites the proliferation of a wide variety of cancer cells including those from prostate (LNCaP, DU145, PC3), breast (MCF-7, MDA-MB231), non-small cell lung (NSCL) (NCI-H520, NCI-H460, NCI-H1299) cancers, acute promyelocytic leukemia (NB4), and glioblastoma multiforme (U118, U138) with ED50s ranging from 1.8 to 7.5 μg/ml. [1] The antitumor activities of Oridonin may due to its inhibitory effects on NF-kappaB and MAPKs signal pathways. [2] [3]
in vivo

LD50: Mice 35-40mg/kg. [4]

プロトコル(参考用のみ)

カスタマーフィードバック

Data from [Data independently produced by , , Int J Mol Sci, 2018, 19(8)]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Oridonin attenuates the progression of atherosclerosis by inhibiting NLRP3 and activating Nrf2 in apolipoprotein E-deficient mice [ Inflammopharmacology, 2023, 31(4):1993-2005] PubMed: 37155118
Network-Based Method to Investigate the Promoted Cell Apoptosis Mechanisms of Oridonin in OSCC through the RNA-Transcriptome [ J Immunol Res, 2023, 2023:5293677] PubMed: 36969496
FBW7-mediated ubiquitination and destruction of PD-1 protein primes sensitivity to anti-PD-1 immunotherapy in non-small cell lung cancer [ J Immunother Cancer, 2022, 10(9)e005116] PubMed: 36104103
Oridonin alleviates hyperbilirubinemia through activating LXRα-UGT1A1 axis [ Pharmacol Res, 2022, 178:106188] PubMed: 35338002
Effect of oridonin on oxylipins in the livers of mice with acute liver injury induced by D-galactosamine and lipopolysaccharide [ Int Immunopharmacol, 2022, 102:108387] PubMed: 34838489
Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway [ BMC Complement Med Ther, 2022, 22(1):180] PubMed: 35799227
Oridonin Relieves Angiotensin II-Induced Cardiac Remodeling via Inhibiting GSDMD-Mediated Inflammation [ Cardiovasc Ther, 2022, 2022:3167959] PubMed: 35360548
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation [ J Exp Med, 2021, 218(9)e20202637] PubMed: 34342641
Eryptosis and Malaria: New Experimental Guidelines and Re-Evaluation of the Antimalarial Potential of Eryptosis Inducers [ Front Cell Infect Microbiol, 2021, 11:630812] PubMed: 33777843
Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin [ J Nat Prod, 2021, 10.1021/acs.jnatprod.0c01231] PubMed: 33890470

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。