受注:045-509-1970 |
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Synonyms | NSC-9900 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C21H28O5 |
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分子量 | 360.44 | CAS No. | 50-24-8 | |
Solubility (25°C)* | 体外 | DMSO | 72 mg/mL (199.75 mM) | |
Ethanol | 10 mg/mL (27.74 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. |
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in vitro | Prednisolone (50 mg/kg, im) given 15 min before LPS-attenuated production of NO2- and NO3- by neutrophils and suppresses LPS-stimulated mRNA for NOS II in rat neutrophils. [1] Prednisolone reduces joint swelling through a mechanism associated with a reduction in IL-1beta and IL-6 protein and mRNA expression levels in SCW-induced arthritis rats. [2] Prednisolone's anti-inflammatory effects can be mediated by reducing cellular adhesion molecule (CAM) expression. Prednisolone (0.75 mg/kg) reduces macrophages (-59%, -57%), CD4(+) T-cells (-50%, -60%), CD8(+) T-cells (-58%, -48%), and eosinophils (-36%, -25%) in quadriceps and soleus muscles, respectively. Prednisolone-treated mice also exhibits decreased vascular P-selectin (-82%) and ICAM-1 (-52%) expression and fewer L-selectin (-79%) and ICAM-1 (-57%) expressing mononuclear cells in quadriceps. Prednisolone reduces sarcolemmal damage and degeneration as well in Dystrophin-deficient, mdx mice. [3] |
in vivo | Prednisolone (5 mg/kg) causes alterations in diaphragmatic contractile properties and histological changes without fiber atrophy in rats. Prednisolone results in an increased number of diaphragmatic bundles in rats. [4] Prednisolone induces a significant decline of PL-pO2, while CoBF, CMs, CAPs, and ABRs revealed no change in guinea pigs. [5] |
, , PLoS One, 2014, 9(12):e111840.
Data from [Data independently produced by , , Leuk Lymphoma, 2014, 55(5):1144-50. ]
PRMT5 triggers glucocorticoid-induced cell migration in triple-negative breast cancer [ Life Sci Alliance, 2023, 6(10)e202302009] | PubMed: 37536978 |
PRMT5 triggers glucocorticoid-induced cell migration in triple-negative breast cancer [ Life Sci Alliance, 2023, 6(10)e202302009] | PubMed: 37536978 |
Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways [ Front Oncol, 2022, 12:905665] | PubMed: 36119546 |
Application of a newly-developed cynomolgus macaque BiTE-mediated cytotoxic T-lymphocyte activity assay to various immunomodulatory agents in vitro [ J Immunotoxicol, 2021, 18(1):154-162] | PubMed: 34714999 |
In vitro effect of biological and conventional disease-modifying antirheumatic drugs on fibrocyte differentiation in patients with rheumatoid arthritis and healthy controls [ Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054] | PubMed: 34059186 |
Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels [ Int J Biol Sci, 2020, 16(13):2382-2391] | PubMed: 32760206 |
WEE1 inhibition synergizes with CHOP chemotherapy and radiation therapy through induction of premature mitotic entry and DNA damage in diffuse large B-cell lymphoma [ Ther Adv Hematol, 2020, 11:2040620719898373] | PubMed: 32010435 |
WEE1 inhibition synergizes with CHOP chemotherapy and radiation therapy through induction of premature mitotic entry and DNA damage in diffuse large B-cell lymphoma. [ Ther Adv Hematol, 2020, 11:2040620719898373] | PubMed: 32010435 |
High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction [ Drug Test Anal, 2020, 10.1002/dta.2917] | PubMed: 32852861 |
A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity. [ Elife, 2019, 8] | PubMed: 31742555 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
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