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Synonyms | Kakonein | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C21H20O9 |
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分子量 | 416.38 | CAS No. | 3681-99-0 | |
Solubility (25°C)* | 体外 | DMSO | 86 mg/mL (206.54 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. |
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in vitro | Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. [1] Pueraria is employed clinically to treat cardiovascular diseases in China. [2] Another study showed that puerarin also possessed anti-cancer properties. Puerarin at 25 μM dose-dependently reduces HT-29 cellular growth with an increase of bax and decreases of c-myc and bcl-2. [3] |
in vivo | In hypercholesterolmic diet plus administration of puerarin (300 mg/kg/day, p.o.) rats, Puerarin markedly attenuated the increased total cholesterol induced by hypercholesterolmic diet in both serum and liver. [2] LD50: Mice 738mg/kg (i.v.) [4] |
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Puerarin Prevents Cadmium-Induced Neuronal Injury by Alleviating Autophagic Dysfunction in Rat Cerebral Cortical Neurons [ Int J Mol Sci, 2023, 24(9)8328] | PubMed: 37176033 |
Puerarin alleviates cadmium-induced rat neurocyte injury by alleviating Nrf2-mediated oxidative stress and inhibiting mitochondrial unfolded protein response [ Ecotoxicol Environ Saf, 2022, 247:114239] | PubMed: 36326556 |
Puerarin attenuates cisplatin-induced apoptosis of hair cells through the mitochondrial apoptotic pathway [ Biochim Biophys Acta Mol Cell Res, 2022, S0167-4889(21)00262-7] | PubMed: 35032475 |
Puerarin Restores Autophagosome-Lysosome Fusion to Alleviate Cadmium-Induced Autophagy Blockade via Restoring the Expression of Rab7 in Hepatocytes [ Front Pharmacol, 2021, 12:632825] | PubMed: 33935722 |
Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors [ Int J Mol Sci, 2020, 21(14):5025] | PubMed: 32708687 |
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] | PubMed: 30900754 |
Puerarin Decreases Collagen Secretion in AngII-Induced Atrial Fibroblasts Through Inhibiting Autophagy Via the JNK-Akt-mTOR Signaling Pathway. [ J Cardiovasc Pharmacol, 2019, 73(6):373-382] | PubMed: 31162246 |
Colloidal Aggregation and the in vitro Activity of Traditional Chinese Medicines. [Duan D, et al. ACS Chem Biol, 2015, 10.1021/cb5009487] | PubMed: 25606714 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。