Quercetin

製品コードS2391 バッチS239104

印刷

化学情報

Synonyms

Sophoretin, C.I. 75720, NSC 9221

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₅H₁₀O₇

分子量

302.24

CAS No.

117-39-5

Solubility (25°C)*

体外

DMSO

60 mg/mL (198.51 mM)

Ethanol

4 mg/mL (13.23 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Clear solution

5%DMSO 1 Corn oil

7.5mg/ml

Taking the 1 mL working solution as an example, add 50 μL of 150 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.
in vitro	Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. ^[1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. ^[2]
in vivo	Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.^[3] LD50: >3000mg/kg (i.g.) ^[4]

製品説明

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.

in vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. ^[1]

Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. ^[2]

in vivo

Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.^[3]

LD50: >3000mg/kg (i.g.) ^[4]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Sertoli cells
	濃度	0.1 μM
	反応時間	24 h
	実験の流れ	Cells were treated with various concentrations of drug for 24 h.
動物実験	動物モデル	Mice bearing LNCaP xenografts or PC-3 xenografts
	投薬量	75mg/kg
	投与方法

参考

カスタマーフィードバック

: Data independently produced by Dr. Zhang of Tianjin Medical University, 2011

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Cellular senescence primes liver fibrosis regression through Notch-EZH2 [ MedComm (2020), 2023, 4(5):e346]	PubMed: 37614965
Cellular senescence primes liver fibrosis regression through Notch-EZH2 [ MedComm -2020), 2023, 4(5):e346]	PubMed: 37614965
Treatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice [ Aging Cell, 2023, e13771.]	PubMed: 36704839
Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence through Its Unique Domain [ Cells, 2023, 12(3)380]	PubMed: 36766726
Investigation of the mechanism of Prunella vulgaris in treatment of papillary thyroid carcinoma based on network pharmacology integrated molecular docking and experimental verification [ Medicine (Baltimore), 2023, 102(17):e33360]	PubMed: 37115092
A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice [ Nat Commun, 2022, 13(1):7028]	PubMed: 36396643
An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile [ J Exp Clin Cancer Res, 2022, 41(1):86]	PubMed: 35260172
Local Elimination of Senescent Cells Promotes Bone Defect Repair during Aging [ ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138]	PubMed: 35014784
Aqueous extract of Taxus chinensis var. mairei targeting CD47 enhanced antitumor effects in non-small cell lung cancer [ Biomed Pharmacother, 2022, 154:113628]	PubMed: 36058145
Probing the Potential Mechanism of Quercetin and Kaempferol against Heat Stress-Induced Sertoli Cell Injury: Through Integrating Network Pharmacology and Experimental Validation [ Int J Mol Sci, 2022, 23-1911163]	PubMed: 36232461

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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