|
受注：045-509-1970 |
技術サポート：[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
化学情報
|
Synonyms | ZK-62711, SB 95952 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
| 化学式 | C16H21NO3 |
|||
| 分子量 | 275.34 | CAS No. | 61413-54-5 | |
| Solubility (25°C)* | 体外 | DMSO | 55 mg/mL (199.75 mM) | |
| Ethanol | 55 mg/mL warmed with 50ºC water bath (199.75 mM) | |||
| Water | Insoluble | |||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
||||
溶剤液（一定の濃度）を調合する
生物活性
| 製品説明 | The PDE4 selective inhibitor, Rolipram, inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent. |
|---|
プロトコル(参考用のみ)
カスタマーフィードバック
-
Data from [Data independently produced by , , Mol Cancer Ther, 2014, 13(10):2463-73.]
-
Data from [Data independently produced by , , Biomed Pharmacother, 2018, 99:947-955]
-
Data from [Data independently produced by , , J Sex Med, 2016, 13(12):1834-1843]
Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：
| P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis [ Elife, 2022, 11e73511] | PubMed: 35311647 |
| Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson's disease models [ Acta Pharmacol Sin, 2021, 10.1038/s41401-021-00768-4] | PubMed: 34531546 |
| Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA [ Antioxidants (Basel), 2021, 10(3)460] | PubMed: 33809405 |
| Release of adenosine-induced immunosuppression: Comprehensive characterization of dual A2A/A2B receptor antagonist [ Int Immunopharmacol, 2021, 96:107645] | PubMed: 33894488 |
| The protective effect of the PDE-4 inhibitor rolipram on intracerebral haemorrhage is associated with the cAMP/AMPK/SIRT1 pathway [ Sci Rep, 2021, 11(1):19737] | PubMed: 34611179 |
| MicroRNA-30d-5p ameliorates lipopolysaccharide-induced acute lung injury via activating AMPKα [ Immunopharmacol Immunotoxicol, 2021, 43(4):431-442] | PubMed: 34157933 |
| Roflupram exerts neuroprotection via activation of CREB/PGC-1α signalling in experimental models of Parkinson's disease. [ Br J Pharmacol, 2020, 177(10):2333-2350] | PubMed: 31972868 |
| Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway [ Int Immunopharmacol, 2020, S1567-5769(20)33643-2] | PubMed: 33243606 |
| The diacylglycerol kinase α (DGKα)/Akt/NF-κB feedforward loop promotes esophageal squamous cell carcinoma (ESCC) progression via FAK-dependent and FAK-independent manner [ Oncogene, 2019, 38(14):2533-2550] | PubMed: 30532074 |
| Phosphodiesterase-4 inhibition confers a neuroprotective efficacy against early brain injury following experimental subarachnoid hemorrhage in rats by attenuating neuronal apoptosis through the SIRT1/Akt pathway [Li Q, et al. Biomed Pharmacother, 2018, 99:947-955] | PubMed: 29710495 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。