Salidroside

製品コードS2396 バッチS239603

化学情報

	Synonyms	Rhodioloside	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₄H₂₀O₇
	分子量	300.3	CAS No.	10338-51-9
Solubility (25°C)*	体外	DMSO	60 mg/mL (199.8 mM)
		Water	60 mg/mL (199.8 mM)
		Ethanol	22 mg/mL (73.26 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties.
in vitro	Salidroside inhibits the growth of various human cancer cell lines in concentration- and time-dependent manners, and the sensitivity to salidroside is different in those cancer cell lines. Salidroside could cause G1-phase or G2-phase arrest in different cancer cell lines, meanwhile, salidroside resultes in a decrease of CDK4, cyclin D1, cyclin B1 and Cdc2, and upregulates the levels of p27(Kip1) and p21(Cip1). ^[1] Salidroside also alleviates cell viability loss and apoptotic cell death induced by H(2)O(2) stimulation in cultured NGF-differentiated PC12 cells by activating ERK1/2 pathway and inhibiting caspase-3 activation. ^[2] Salidroside activates the PI3K/Akt pathway resulting in protective effects against MPP(+)-induced apoptosis in PC12 cells, which may be used in the treatment of Parkinson's disease (PD). ^[3]
in vivo	Salidroside (20, 50 and 100 mg/kg) protects liver tissue from the oxidative stress elicited by D-galactosamine and lipopolysaccharide. ^[4]

プロトコル(参考用のみ)

参考

[4] Wu YL, et al. J Pharm Pharmacol, 2009, 61(10), 1375-1382.

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy [ Mol Med Rep, 2023, 27(2)37]	PubMed: 36579660
Network pharmacology approach and experimental verification of salidroside in the treatment of hepatocellular carcinoma [ Research Square, 2023, 10.21203/rs.3.rs-3696850/v1]	PubMed: none
The LPS induced pyroptosis exacerbates BMPR2 signaling deficiency to potentiate SLE-PAH [ FASEB J, 2021, 35(12):e22044]	PubMed: 34818449
Protective Effect of Salidroside on Mitochondrial Disturbances via Reducing Mitophagy and Preserving Mitochondrial Morphology in OGD-induced Neuronal Injury [ Curr Med Sci, 2021, 10.1007/s11596-021-2374-6]	PubMed: 34181207
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447]	PubMed: 30900754

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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