Toremifene Citrate (NK 622)

製品コードS1776 バッチS177601

印刷

化学情報

Chemical Structure Synonyms NSC 613680,NK 622 Citrate Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C32H36ClNO8
分子量 598.08 CAS No. 89778-27-8
Solubility (25°C)* 体外 DMSO 120 mg/mL (200.64 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Toremifene Citrate (NK 622, NSC 613680) is an oral selective estrogen receptor modulator (SERM), used in the treatment of advanced breast cancer.
in vitro Toremifene (7.5 mM) causes approximately 60% of the cells to exhibit morphologic characteristics typical of cells undergoing programmed death, or apoptosis in human breast cancer cells. Toremifene (5-10 mM) results in elevated levels of TRPM-2 and TGF beta 1 mRNAs in in vitro or in vivo grown tumor cells. Toremifene causes growth inhibition of estrogen-sensitive breast cancer cells by inducing some cells to undergo apoptosis and by inhibiting other cells from entering mitosis. [1] Toremifene induces a dose-dependent level of adducts that is lower than that observed for TAM. Toremifene significantly enhances endogenous DNA adduct formation. [2] Toremifene affects the cell turnover by inhibiting mitotic activity and modifying abundant spontaneous apoptosis in DMBA-induced rat mammary carcinoma. [3]
in vivo Toremifene, at the highest tested dose, increases the incidence of hepatocellular carcinomas in the DEN-initiated groups to a level one-third that observed with Tamoxifen administration to DEN-initiated rats. Toremifene increases the incidence of hypernephromas in previously DEN-initiated rats. [4] Toremifene results in aneuploidy in 50% of the cells examined and compared with the 85% level induced by Tamoxifen in female Sprague-Dawley rats. [5]

プロトコル(参考用のみ)

カスタマーフィードバック

Data from [Data independently produced by , , Nature, 2018, 560(7718):372-376]

Data from [Data independently produced by , , J Biomed Res, 2016, 30(5): 393-410.]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Hormonally Regulated Myogenic miR-486 Influences Sex-specific Differences in Cancer-induced Skeletal Muscle Defects [ Endocrinology, 2021, 162(10)bqab142] PubMed: 34265069
Reversal of Infected Host Gene Expression Identifies Repurposed Drug Candidates for COVID-19 [ bioRxiv, 2020, 2020/9/20.4.7.30734] PubMed: 32511305
Arbidol and Other Low-Molecular-Weight Drugs That Inhibit Lassa and Ebola Viruses. [ J Virol, 2019, 93(8)] PubMed: 30700611
Inhibition of Ebola Virus by a Molecularly Engineered Banana Lectin. [ PLoS Negl Trop Dis, 2019, 13(7):e0007595] PubMed: 31356611
Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination [Hubler Z, et al. Nature, 2018, 560(7718):372-376] PubMed: 30046109
Comparative analysis of media effects on human induced pluripotent stem cell-derived cardiomyocytes in proarrhythmia risk assessment [ J Pharmacol Toxicol Methods, 2017, 90:39-47] PubMed: 29155283
New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy. [Paranjpe A, et al. J Biomed Res, 2016, 30(5):393-410] PubMed: 27845303
Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer. [ Nat Commun, 2015, 6:8481] PubMed: 26412466

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。