A-1331852

製品コードS7801 バッチS780103

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C38H38N6O3S
分子量 658.81 CAS No. 1430844-80-6
Solubility (25°C)* 体外 DMSO 100 mg/mL (151.78 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 A-1331852 is a potent and selectiveBCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases.
in vitro A-1331852 exhibits remarkable potency both as a single agent and in combination with TKIs in killing primary CD34+ CML cell. Also, It has remarkable potency in inducing apoptosis in these cells at low nanomolar concentrations as early as 1 h post-treatment[2].
in vivo A-1331852 demonstrates antitumor efficacy in the Molt-4 xenograft model, inducing tumor regressions as a single agent[1].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 K562 cells
濃度 100 nM
反応時間 0-2 h
実験の流れ Immunoprecipitation of BCL-XL is carried out in K562 cells, exposed to A-1331852 (100 nM) for 0-2 h, and the eluted complexes are immunoblotted for the indicated proteins. The input cell lysates and the immunodepleted supernatant (labeled as Flow-through) are immunoblotted to check the efficiency of the immunoprecipitation.
動物実験 動物モデル SCID and SCID-bg mice
投薬量 25 mg/kg
投与方法 Oral administration

カスタマーフィードバック

Data from [Data independently produced by , , Cancer Lett, 2018, 412:131-142]

Data from [Data independently produced by , , Mol Cancer Res, 2016, 14(12):1176-1181]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Gravitational and mechanical forces drive mitochondrial translation [ bioRxiv, 2024, 10.1101/2023.01.18.524628] PubMed: none
Clearance of defective muscle stem cells by senolytics restores myogenesis in myotonic dystrophy type 1 [ Nat Commun, 2023, 14(1):4033] PubMed: 37468473
Single-molecule fingerprinting of protein-drug interaction using a funneled biological nanopore [ Nat Commun, 2023, 14(1):1461] PubMed: 37015934
Increased MCL1 dependency leads to new applications of BH3-mimetics in drug-resistant neuroblastoma [ Br J Cancer, 2023, 10.1038/s41416-023-02430-8] PubMed: 37723317
ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression [ Front Immunol, 2023, 14:1196731] PubMed: 37539056
Bcl-xL is required to protect endothelial cells latently infected with KSHV from virus induced intrinsic apoptosis [ PLoS Pathog, 2023, 19(5):e1011385] PubMed: 37163552
Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma [ iScience, 2023, 26(8):107369] PubMed: 37539026
Systematic characterization of therapeutic vulnerabilities in Multiple Myeloma with Amp1q reveals increased sensitivity to the combination of MCL1 and PI3K inhibitors [ bioRxiv, 2023, 2023.08.01.551480] PubMed: 37577538
Systematic characterization of therapeutic vulnerabilities in Multiple Myeloma with Amp1q reveals increased sensitivity to the combination of MCL1 and PI3K inhibitors [ bioRxiv, 2023, 2023.08.01.551480] PubMed: 37577538
Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer [ Nat Commun, 2022, 13(1):1199] PubMed: 35256598

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。