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Synonyms | AdoMet, S-Adenosylmethionine, SAMe | Storage (From the date of receipt) |
3 years -20°C powder (seal) | |
化学式 | C15H22N6O5S |
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分子量 | 398.44 | CAS No. | 29908-03-0 | |
Solubility (25°C)* | 体外 | DMSO | 80 mg/mL (200.78 mM) | |
Water | 80 mg/mL (200.78 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals. |
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in vitro | Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phospholipids, catecholamines and DNA[1]. |
in vivo | SAMe is able to cross the intestinal wall and increase plasma levels. Studies in rats reveal that absorption of the drug is much better after intraduodenal administration compared to oral administration. The systemic bioavailability after oral SAMe administration appears to be low. SAMe dose-dependently (12.5, 25, 50, 100 and 200 mg/kg sc.) decreases immobility time in the forced swimming test in mice and rats. Chronic treatment with SAMe is associated with an increase in density of b-receptors, and a decrease in the affinity of a1 adrenoceptors for phenylephrine in rat cerebral membranes[1]. |
MAT2A inhibition suppresses inflammation in Porphyromonas gingivalis-infected human gingival fibroblasts [ J Oral Microbiol, 2024, 16(1):2292375] | PubMed: 38130504 |
Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy [ Nat Metab, 2023, 10.1038/s42255-023-00861-4] | PubMed: 37563469 |
Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy [ Nat Metab, 2023, 5(9):1544-1562] | PubMed: 37563469 |
Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss [ FASEB J, 2022, 36(2):e22167] | PubMed: 35064691 |
Identification of SARS-CoV-2-induced pathways reveals drug repurposing strategies [ Sci Adv, 2021, 7(27)eabh3032] | PubMed: 34193418 |
The Roles of Imprinted SLC22A18 and SLC22A18AS Gene Overexpression Caused by Promoter CpG Island Hypomethylation as Diagnostic and Prognostic Biomarkers for Non-Small Cell Lung Cancer Patients [ Cancers (Basel), 2020, 12(8):E2075] | PubMed: 32726996 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。