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Synonyms | Didemethyl Ginkgetin | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C30H18O10 |
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分子量 | 538.46 | CAS No. | 1617-53-4 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (185.71 mM) | |
Ethanol | 100 mg/mL (185.71 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities. |
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in vitro | Amentoflavone induces morphological changes and reduces the percentage of viable MCF-7 cells. Amentoflavone induces apoptosis and chromatin condensation, DNA strand breaks in MCF-7 cells. Amentoflavone is also reported to induce cell-cycle arrest at the sub-G1 phase, and apoptosis via mitochondria-emanated intrinsic pathways in SiHa and CaSki human cervical cancer cells[1]. |
in vivo | In an animal model, amentoflavone is found to significantly inhibit B16F-10 melanoma-induced solid tumor development in C57BL/6 mice[1]. Amentoflavone can cross the blood-brain barrier. It effectively prevents pilocarpine-induced epilepsy in a mouse kindling model, suppresses NF-kB activation and expression, inhibits excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons[2]. |
細胞アッセイ | 細胞株 | MCF-7 cells |
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濃度 | 250 μM | |
反応時間 | 6-72 h | |
実験の流れ | Approximately 2×105 MCF-7 cells/well in 24-well plates are treated with 250 μM amentoflavone, or with vehicle (DMSO, 0.1% in culture media)-only and all cells are incubated for 6 to 72 h. For the examination of morphological changes, cells are photographed under a phase-contrast microscope. | |
動物実験 | 動物モデル | Kunming mice |
投薬量 | 25 mg/kg | |
投与方法 | intragastrically administered |
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New Insights on Structures Forming the Lignin-Like Fractions of Ancestral Plants [ Front Plant Sci, 2021, 12:740923] | PubMed: 34691117 |
Amentoflavone Inhibits HSV-1 and ACV-Resistant Strain Infection by Suppressing Viral Early Infection [ Viruses, 2019, 11(5)E466] | PubMed: 31121928 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。