Aminoguanidine hydrochloride

製品コードS4548 バッチS454801

化学情報

	Synonyms	Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	CH₆N₄.HCl
	分子量	110.55	CAS No.	1937-19-5
Solubility (25°C)*	体外	DMSO	22 mg/mL warmed with 50ºC water bath (199.0 mM)
		Water	22 mg/mL (199.0 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.
in vivo	Aminoguanidine ameliorates neonatal hypoxic-ischemic brain damage and that temporal profiles of NO correlated with the neuroprotective effect of aminoguanidine. Neuroprotection by AG is attributable to suppression of NO produced by iNOS after the end of the hypoxic period, during the reoxygenation phase. The half-life of AG is estimated to be between 6 and 8 h in vivo and approximately 4.4 h in human with normal renal function.AG is also an inhibitor of the formation of advanced glycation end products. Systematically administered advanced glycation end product–modified BSA increases cerebral infarct size in an adult rat, which is attenuated by AG^[2].

製品説明

Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.

in vivo

Aminoguanidine ameliorates neonatal hypoxic-ischemic brain damage and that temporal profiles of NO correlated with the neuroprotective effect of aminoguanidine. Neuroprotection by AG is attributable to suppression of NO produced by iNOS after the end of the hypoxic period, during the reoxygenation phase. The half-life of AG is estimated to be between 6 and 8 h in vivo and approximately 4.4 h in human with normal renal function.AG is also an inhibitor of the formation of advanced glycation end products. Systematically administered advanced glycation end product–modified BSA increases cerebral infarct size in an adult rat, which is attenuated by AG^[2].

プロトコル(参考用のみ)

動物実験	動物モデル	Wister rat pups
	投薬量	300 mg/kg
	投与方法	i.p.

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Effect of calcium-sensing receptor on the migration and proliferation of porcine intestinal epithelial cells [ Anim Biotechnol, 2021, 1-10]	PubMed: 34459707
Effects of spermine on the proliferation and migration of porcine intestinal epithelial cells [ Anim Biotechnol, 2021, 1-8]	PubMed: 34369303
CLIC4 Regulates Radioresistance of Nasopharyngeal Carcinoma by iNOS After γ-rays but Not Carbon Ions Irradiation [ Am J Cancer Res, 2020, 10(5):1400-1415]	PubMed: 32509387
Angiogenesis impairment by the NADPH oxidase-triggered oxidative stress at the bone-implant interface: Critical mechanisms and therapeutic targets for implant failure under hyperglycemic conditions in diabetes [Hu XF, et al. Acta Biomater, 2018, 73:470-487]	PubMed: 29649637
Rapamycin Nano-Micelle Ophthalmic Solution Reduces Corneal Allograft Rejection by Potentiating Myeloid-Derived Suppressor Cells' Function [Wei C, et al. Front Immunol, 2018, 9:2283]	PubMed: 30349533
Lactic acid of PLGA coating promotes angiogenesis on the interface between porous titanium and diabetic bone [ J Mater Chem B, 2018, 6(15):2274-2288]	PubMed: 32254567
Lactic acid of PLGA coating promotes angiogenesis on the interface between porous titanium and diabetic bone [Xiao-Fan Hu, et al. J Mater Chen B, 2018, 10.1039/C7TB03247A]

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。