Apocynin

製品コードS2425 バッチS242502

印刷

化学情報

Chemical Structure Synonyms NSC 2146, Acetovanillone, NSC 209524 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C9H10O3
分子量 166.17 CAS No. 498-02-2
Solubility (25°C)* 体外 DMSO 33 mg/mL (198.59 mM)
Ethanol 33 mg/mL (198.59 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Apocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
in vitro Apocynin is a naturally occurring methoxy-substituted catechol used as an inhibitor of NADPH-oxidase. Apocynin prevents serine phosphorylation of p47phox and blocks its association with gp91phox, thus blunting NADPH oxidase activation. [2] Apocynin can decrease the production of superoxide (O(2)(-)) from activated neutrophils and macrophages. Apocynin, after metabolic conversion, inhibits the assembly of NADPH-oxidase that is responsible for reactive oxygen species (ROS) production. [3]
in vivo Apocynin has anti-inflammatory activity in a variety of cell and animal models of inflammation. Apocynin attenuates the TNF-α and IL-1β production and iNOS expression in the lung of carrageenan-treated mice. [4] Apocynin exerts beneficial effects in a mice model of spinal cord injury. Apocynin reduces (1) the degree of spinal cord damage, (2) neutrophils infiltration, (3) ICAM-1 and P-selectin expression, (4) PAR and nitrotyrosine formation, (5) IκB-α degradation, (6) NF-κB activation, (7) pro-inflammatory cytokines production (TNF-α and IL-1β), (8) apoptosis (TUNEL staining, FAS ligand expression, Bax and Bcl-2 expression) and (9) MAPK activation (P-38 and phospho-JNK). [5] LD50: Mice 9g/kg (i.g.). [3]

プロトコル(参考用のみ)

カスタマーフィードバック

, , Int J Endocrinol, 2016, 2016:8354745.

Data from [Data independently produced by , , Acta Biomater, 2018, 73:470-487]

Data from [Data independently produced by , , Oxid Med Cell Longev, 2017, 2017:9738745]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

NADPH Oxidase-Mediated Testicular Oxidative Imbalance Regulates the TXNIP/NLRP3 Inflammasome Axis Activation after Ischemia Reperfusion Injury [ Antioxidants (Basel), 2023, 12(1)145] PubMed: 36671008
Epicardial Adipose Tissue-Derived Leptin Promotes Myocardial Injury in Metabolic Syndrome Rats Through PKC/NADPH Oxidase/ROS Pathway [ J Am Heart Assoc, 2023, 12(15):e029415] PubMed: 37489731
Simulated microgravity reduces quality of ovarian follicles and oocytes by disrupting communications of follicle cells [ NPJ Microgravity, 2023, 9(1):7] PubMed: 36690655
Fisetin alleviates cellular senescence through PTEN mediated inhibition of PKCδ-NOX1 pathway in vascular smooth muscle cells [ Arch Gerontol Geriatr, 2023, 108:104927] PubMed: 36645971
Tryptophan-sorbitol based carbon quantum dots for theranostics against hepatocellular carcinoma [ J Nanobiotechnology, 2022, 20(1):78] PubMed: 35164792
Indoxyl sulfate reduces Ito,f by activating ROS/MAPK and NF-κB signaling pathways [ JCI Insight, 2022, 7(3)e145475] PubMed: 35132967
The pro-inflammatory effect of Staphylokinase contributes to community-associated Staphylococcus aureus pneumonia [ Commun Biol, 2022, 5(1):618] PubMed: 35739262
Porcine Enteric Coronavirus PEDV Induces the ROS-ATM and Caspase7-CAD-γH2AX Signaling Pathways to Foster Its Replication [ Viruses, 2022, 14(8)1782] PubMed: 36016404
Advanced oxidation protein products induce annulus fibrosus cell senescence through a NOX4-dependent, MAPK-mediated pathway and accelerate intervertebral disc degeneration [ PeerJ, 2022, 10:e13826] PubMed: 35935259
Xanthohumol-Induced Rat Glioma C6 Cells Death by Triggering Mitochondrial Stress [ Int J Mol Sci, 2021, 22(9)4506] PubMed: 33925918

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。