Atorvastatin

製品コードS5715 バッチS571503

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₃₃H₃₅FN₂O₅
	分子量	558.64	CAS No.	134523-00-5
Solubility (25°C)*	体外	DMSO	100 mg/mL (179.0 mM)
		Ethanol	6 mg/mL (10.74 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.
in vitro	Atorvastatin, one of the statins, inhibits the c-Myc pathway in chronic myeloid leukemia (CML) cells, demonstrating that c-Myc is a target of statins.^[1]
in vivo	ATV-Exos activates AKT/eNOS signaling pathway to augment the angiogenesis of endothelial cells via upregulating miR-211-3p, thereby resulting in accelerated wound regeneration of the diabetic rats.^[2]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	murine CML-KLS⁺ cells, OP-9 stromal cells
	濃度	2 μM
	反応時間	3 days
	実験の流れ	CML cKit+Lineage Sca1+ (KLS) cells are isolated from CML mice. Thereafter, the effect of statins on the colony-forming capacity of CML-KLS cells is determined. Freshly isolated CML-KLS cells are co-cultured with OP-9 stromal cells in the presence of IM (1 M), DA (0.5 M), and rosuvastatin (2 M) or atorvastatin (2 M) for 72 h. Thereafter, the cells are washed with PBS and transferred to semi-solid medium. The number of colonies is counted under the microscope.
動物実験	動物モデル	Sprague-Dawley rats ofdiabetes models
	投薬量	50 μg/mL
	投与方法	s.c

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

High glutamine increases stroke risk by inducing the endothelial-to-mesenchymal transition in moyamoya disease [ MedComm (2020), 2024, 5(5):e525]	PubMed: 38628905
The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia [ Oncogene, 2024, 43(4):281-293]	PubMed: 38030791
Clinically conserved genomic subtypes of gastric adenocarcinoma [ Mol Cancer, 2023, 22(1):147]	PubMed: 37674200
Clinically conserved genomic subtypes of gastric adenocarcinoma [ Mol Cancer, 2023, 22(1):147]	PubMed: 37674200
RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence [ Oncogene, 2023, 42(21):1716-1727]	PubMed: 37029299
Lipophilic Statins Eliminate Senescent Endothelial Cells by inducing Anoikis-Related Cell Death [ Cells, 2023, 12(24)2836]	PubMed: 38132158
Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML [ Int J Mol Sci, 2023, 24(4)4235]	PubMed: 36835644
Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasis [ Oncogene, 2022, 41(39):4446-4458]	PubMed: 36008464
In Vitro Evidence of Statins' Protective Role against COVID-19 Hallmarks [ Biomedicines, 2022, 10(9)2123]	PubMed: 36140223
In situ assessment of statins' effect on autophagic activity in zebrafish larvae cardiomyocytes [ Front Cardiovasc Med, 2022, 9:921829]	PubMed: 36465443

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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