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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | 2(C33H34FN2O5).Ca |
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分子量 | 1155.34 | CAS No. | 134523-03-8 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (86.55 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy. |
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in vitro | Atorvastatin inhibits pre-proET-1 mRNA expression in a concentration- and time-dependent fashion (60-70% maximum inhibition) and reduces immunoreactive ET-1 levels (25-50%), this inhibitory effect is maintained in the presence of oxidized LDL (1-50 mg/mL). [1] Atorvastatin significantly reduces angiotensin II-induced and epidermal growth factor-induced ROS production in VSMCs. Atorvastatin downregulates mRNA expression of the NAD(P)H oxidase subunit nox1 in VSMCs, whereas p22phox mRNA expression is not significantly altered. Atorvastatin inhibits membrane translocation of rac1 GTPase, which is required for the activation of NAD(P)H oxidase. [2] Atorvastatin (0.1 μM) significantly diminishes NF-κB activation induced by Ang II and TNF-α in mononuclear cells and VSMC. Atorvastatin (1 μM) diminishes MCP-1 expression induced by Ang II, TNF-α and is reversed by Mevalonate only in Ang II-stimulated cells. Atorvastatin (1 μM) diminishes IP-10 expression induced by Ang II and by TNF-α in VSMC, and this reduction is partially reversed by Mevalonate. [3] Atorvastatin and Gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation. [4] |
in vivo | Atorvastatin reduces vascular mRNA expression of p22phox and nox1 and increased aortic catalase expression in statin-treated rats. [2] Atorvastatin inhibits the increase of hsCRP serum levels in the cholesterol-fed rabbits. Atorvastatin inhibits the increase in osteopontin expression throughout the valve leaflet in the hypercholesterolemic aortic valves. [5] |
細胞アッセイ | 細胞株 | BAECs |
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濃度 | 10 μM | |
反応時間 | 24 h | |
実験の流れ | Cells were treated with indicated concentration of the drug for 24 hour. |
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動物実験 | 動物モデル | Male New Zealand White rabbits |
投薬量 | 3 mg/kg | |
投与方法 | p.o. |
Data from [BMC Pharmacol Toxicol, 2013, 14, 15]
Upregulation of the Mevalonate Pathway through EWSR1-FLI1/EGR2 Regulatory Axis Confers Ewing Cells Exquisite Sensitivity to Statins [ Cancers (Basel), 2022, 14(9)2327] | PubMed: 35565457 |
Ultra-fast proteomics with Scanning SWATH [ Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4] | PubMed: 33767396 |
The thrombin receptor links brain derived neurotrophic factor to neuron cholesterol production, resiliency and repair after spinal cord injury [ Neurobiol Dis, 2021, 152:105294] | PubMed: 33549720 |
Atorvastatin potentiates the chemosensitivity of human liver cancer cells to cisplatin via downregulating YAP1 [ Oncol Lett, 2021, 21(2):82] | PubMed: 33363619 |
The MEK5-ERK5 kinase axis controls lipid metabolism in small cell lung cancer. [ Cancer Res, 2020, canres.1027.2019] | PubMed: 31969375 |
Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway [ Stem Cell Res Ther, 2020, 11(1):350] | PubMed: 32787917 |
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition. [ Nat Commun, 2019, 10(1):96] | PubMed: 30626880 |
Ruxolitinib and Polycation Combination Treatment Overcomes Multiple Mechanisms of Resistance of Pancreatic Cancer Cells to Oncolytic Vesicular Stomatitis Virus [ J Virol, 2017, 91(16)e00461-17] | PubMed: 28566376 |
Lovastatin induces apoptosis of HepG-2 cells by activating ROS-dependent mitochondrial and ER stress pathways [ Int J Clin Exp Pathol, 2017, 10(12):11480-11488] | PubMed: 31966503 |
Bioenergetic study of murine hepatic tissue treated in vitro with atorvastatin. [Alfazari AS, et al. BMC Pharmacol Toxicol, 2013, 14:15] | PubMed: 23448291 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。