受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | (S)-(+)-Bakuchiol | Storage (From the date of receipt) |
1 year -80°C in solvent | |
化学式 | C18H24O |
|||
分子量 | 256.38 | CAS No. | 10309-37-2 | |
Solubility (25°C)* | 体外 | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities. | |||||
---|---|---|---|---|---|---|
in vitro | Bakuchiol inhibits EGF-induced signaling pathways downstream of Hck, Blk and p38 MAPK, including the MEK/ERKs, p38 MAPK/MSK1 and AKT/p70S6K pathways. Bakuchiol decreases viability and inhibits anchorage-independent growth of A431 human epithelial carcinoma cells. It also inhibits the proliferation of A549 human lung adenocarcinoma cells, SK-MEL-2 human melanoma cells and B16 mouse melanoma cells by inducing apoptosis[1]. | |||||
in vivo | Bakuchiol reduces A431 xenograft tumor growth in an in vivo mouse model[1]. Bakuchiol treatment attenuates acute lung injury following sepsis by suppressing inflammation, oxidative stress, and endothelial barrier disruption[2]. | |||||
密度 | 0.96 g/mL |
細胞アッセイ | 細胞株 | HaCaT and JB6 P+ cells |
---|---|---|
濃度 | 0, 5, 10, and 20 μM | |
反応時間 | 1 h | |
実験の流れ | Cells (1.5 × 106) are cultured in 100-mm dishes for 48 h, and then serum starved in 0.1% FBS-MEM for 24 h. The cells are then treated with bakuchiol (0, 5, 10, and 20 μM) for 1 h before exposure to 10 ng/ml EGF for an additional 30 min. Cells are harvested and disrupted with lysis buffer before protein concentration is measured using a dye-binding protein assay kit. |
|
動物実験 | 動物モデル | 6-week-old, BALB/c-nu mice |
投薬量 | 10 or 40 mg/kg | |
投与方法 | i.p. |
|
Effects of Bakuchiol on chondrocyte proliferation via the PI3K-Akt and ERK1/2 pathways mediated by the estrogen receptor for promotion of the regeneration of knee articular cartilage defects. [ Cell Prolif, 2019, 52(5):e12666] | PubMed: 31407423 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。