BAPTA-AM

製品コードS7534 バッチS753402

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C34H40N2O18
分子量 764.68 CAS No. 126150-97-8
Solubility (25°C)* 体外 DMSO 100 mg/mL (130.77 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 BAPTA-AM is a selective, membrane-permeable calcium chelator.
in vitro

BAPTA-AM, as an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. [1]

BAPTA-AM exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels with IC50 of 1.3, 1.45 and 1.23 μM in HEK 293 cells. [2]
in vivo

BAPTA-AM abolishes the UDCA- and TUDCA-induced increases in Ca2+ levels or Ca2+-Dependent PKC-α phosphorylation, and neutralizes the cytoprotective effects of UDCA and TUDCA on the vagotomy-induced damage of the biliary tree in the BDL rats. [3]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Astrocytes
濃度 10 μM
反応時間
実験の流れ
動物実験 動物モデル BDL rats
投薬量 ~6 mg/kg
投与方法 i.p.

カスタマーフィードバック

, , J Cell Mol Med, 2017, 21(7):1373-1387

Data from [Data independently produced by , , Acta Pharm Sin B, 2018, 8(6):909-918]

Data from [Data independently produced by , , CNS Neurosci Ther, 2017, 23(4):291-300]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Ammonia stress-induced heat shock factor 1 enhances white spot syndrome virus infection by targeting the interferon-like system in shrimp [ mBio, 2024, e0313623.] PubMed: 38358252
The delta subunit of the GABAA receptor is necessary for the GPT2-promoted breast cancer metastasis [ Theranostics, 2023, 13(4):1355-1369] PubMed: 36923530
Uptake-independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates [ EMBO J, 2023, e113490.] PubMed: 36920246
CRTAC1 enhances the chemosensitivity of non-small cell lung cancer to cisplatin by eliciting RyR-mediated calcium release and inhibiting Akt1 expression [ Cell Death Dis, 2023, 10.1038/s41419-023-06088-1] PubMed: 37633993
CRTAC1 enhances the chemosensitivity of non-small cell lung cancer to cisplatin by eliciting RyR-mediated calcium release and inhibiting Akt1 expression [ Cell Death Dis, 2023, 14(8):563] PubMed: 37633993
IP3R-dependent mitochondrial dysfunction mediates C5b-9-induced ferroptosis in trichloroethylene-caused immune kidney injury [ Front Immunol, 2023, 14:1106693] PubMed: 37383224
Porcine reproductive and respiratory syndrome virus infection triggers autophagy via ER stress-induced calcium signaling to facilitate virus replication [ PLoS Pathog, 2023, 19(3):e1011295] PubMed: 36972295
Dextran sodium sulfate potentiates NLRP3 inflammasome activation by modulating the KCa3.1 potassium channel in a mouse model of colitis [ Cell Mol Immunol, 2022, 19(8):925-943] PubMed: 35799057
Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair [ Nat Cell Biol, 2022, 24(6):825-832] PubMed: 35654840
Piezo1-mediated mechanosensation in bone marrow macrophages promotes vascular niche regeneration after irradiation injury [ Theranostics, 2022, 12(4): 1621-1638] PubMed: N/A

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。