BAY 41-2272

製品コードS8128 バッチS812801

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C20H17FN6
分子量 360.39 CAS No. 256376-24-6
Solubility (25°C)* 体外 DMSO 35 mg/mL (97.11 mM)
Ethanol 4 mg/mL warmed with 50ºC water bath (11.09 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
in vitro In vitro, BAY 41-2272 results in concentration dependent relaxation of human and rabbit cavernosum with EC50 of 489.1 nM and 406.3 nM, respectively. [3]
in vivo In female spontaneously hypertensive rats, BAY 41-2272 (10 mg/kg, p.o.) shows antiplatelet effect, strongly decreases blood pressure and increases survival. [2] In C. albicans-infected mice, BAY 41-2272 (10 mg/kg, i.p.) markedly increases macrophage-dependent cell influx to the peritoneum in addition to macrophage functions, and reduces the death rate. [4] In db/db-/- type II diabetic and obese mice, BAY 41-2272 improves impaired corpus cavernosum (CC) relaxation. [5]

プロトコル(参考用のみ)

キナーゼアッセイ Purification of soluble guanylate cyclase (sGC) and determination of sGC activity
sGC is highly purified from a baculovirus/Sf9 expression system and enzyme activity is measured by formation of [32P]-cGMP from [α-32P]-GTP modifiedin the presence of Mg2+. Incubations are performed in the presence and absence of 1 mM DTT. All measurements are performed in duplicate and are repeated three times unless otherwise indicated. The specific activity of sGC is calculated as nmol cGMP formed per mg protein per min incubation time. For characterization of the different sGC stimulators the specific activity of sGC is expressed as x-fold stimulation vs. specific basal activity. The highest DMSO concentration in the test is 1% (v/v) and did not elicit any effect per se on cGMP production.
動物実験 動物モデル Female spontaneously hypertensive rats
投薬量 1 mg/kg
投与方法 p.o.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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