受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
||||
化学式 | C23H31N3O4S2 |
||||||
分子量 | 477.64 | CAS No. | 130370-60-4 | ||||
Solubility (25°C)* | 体外 | DMSO | 96 mg/mL (200.98 mM) | ||||
Water | Insoluble | ||||||
Ethanol | Insoluble | ||||||
体内 (毎回新しく調製した物を用意してください) |
|
||||||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17. |
---|---|
in vitro | Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. [1] Batimastat exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site. [2] |
in vivo | Batimastat can inhibit metastatic spread and growth of B16-BL6 murine melanoma. [1] In an orthotopic colon tumor model in mice, timastat treatment results in inhibition of primary tumor growth (by 50%), local/regional spread(from 67% to 35%), and distant metastasis(from 30% to 10%).[3] Batimastat reduces in vivo growth of experimental hemangiomas, most probably by blocking endothelial cell recruitment by the transformed cells or by interfering with cell organization in vascular structures. [4] |
キナーゼアッセイ | Enzyme assays | |
---|---|---|
IC50s are determined for batimastat in vitro against different metalloproteinases in enzyme assays. | ||
細胞アッセイ | 細胞株 | B16-BL6 cells |
濃度 | 3 nM (MMP-1), 4 nM (MMP-2 & MMP-9), 6 nM (MMP-7) and 20 nM (MMP-3), respectively | |
反応時間 | 22 h | |
実験の流れ | Cells were treated with different concentrations of batimastat was dissolved in absolute ethanol and were incubated for 22 hr and IC50 was measured. |
|
動物実験 | 動物モデル | Nude mouse |
投薬量 | 30mg/ml | |
投与方法 | i.p. |
Data from [Data independently produced by , , Nature, 2017, 549(7673):533-537]
Data from [Data independently produced by , , PLoS One, 2015, 10(5): e0127063]
Data from [Data independently produced by , , Biomed Rep, 2016, 4(1):73-78. ]
Omicron Spike confers enhanced infectivity and interferon resistance to SARS-CoV-2 in human nasal tissue [ Nat Commun, 2024, 15(1):889] | PubMed: 38291024 |
Amino-terminally elongated Aβ peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brains [ Neuropathol Appl Neurobiol, 2024, 50(3):e12991] | PubMed: 38867123 |
Extracellularly Detectable Electrochemical Signals of Living Cells Originate from Metabolic Reactions [ Adv Sci (Weinh), 2023, e2207084.] | PubMed: 36737855 |
FAP is critical for ovarian cancer cell survival by sustaining NF-κB activation through recruitment of PRKDC in lipid rafts [ Cancer Gene Ther, 2023, 30(4):608-621] | PubMed: 36494579 |
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation [ Sci Adv, 2023, 9(7):eade8939] | PubMed: 36791204 |
Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells [ Nat Commun, 2022, 13(1):5494] | PubMed: 36123372 |
Matrix remodeling controls a nuclear lamin A/C-emerin network that directs Wnt-regulated stem cell fate [ Dev Cell, 2022, S1534-5807(22)00040-5] | PubMed: 35150612 |
Systematic analysis of the MAPK signaling network reveals MAP3K-driven control of cell fate [ Cell Syst, 2022, 13(11):885-894.e4] | PubMed: 36356576 |
Complete abrogation of key osteoclast markers with a membrane-anchored tissue inhibitor of metalloproteinase : a novel approach in the prevention of osteoclastogenesis [ Bone Joint Res, 2022, 11(11):763-776] | PubMed: 36331083 |
Aberrant NF-κB activation in odontoblasts orchestrates inflammatory matrix degradation and mineral resorption [ Int J Oral Sci, 2022, 14(1):6] | PubMed: 35082271 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。