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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | ||||||||
化学式 | C19H15Cl2NO4S |
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分子量 | 424.30 | CAS No. | 943962-47-8 | ||||||||
Solubility (25°C)* | 体外 | DMSO | 85 mg/mL (200.32 mM) | ||||||||
Water | Insoluble | ||||||||||
Ethanol | Insoluble | ||||||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | BMS-303141 is a potent, cell-permeable inhibitor of ATP-citrate lyase (ACL) with IC50 of 0.13 μM. BMS-303141 shows inhibition of total lipid syntheses with IC50 of 8 μM in HepG2 cells. |
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in vitro | In HepG2 cells, BMS-303141 shows inhibition of total lipid syntheses with an IC50 of 8 μM, and no cytotoxicity up to 50 lM under a cell based Alamar Blue cytotoxicity assay.[2] |
in vivo | BMS-303141 lowers approximate 20-30% plasma cholesterol and triglycerides, as well as 30-50% fasting plasma glucose in high-fat fed mice.[2] |
細胞アッセイ | 細胞株 | HepG2 cells |
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濃度 | -- | |
反応時間 | 6 h | |
実験の流れ | Inhibition of total lipid synthesis assay. HepG2 cells are incubated for 6 h after addition of the testing compound and [14C]-alanine is added for the last 4 h of incubation. Cell lipids are extracted, separated by TLC. The incorporation of [14C]-labeled in the total lipids is measured. |
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動物実験 | 動物モデル | high-fat fed mice |
投薬量 | 10 or 100 mg/kg | |
投与方法 | o.g. |
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ATP-citrate lyase controls endothelial gluco-lipogenic metabolism and vascular inflammation in sepsis-associated organ injury [ Cell Death Dis, 2023, 14(7):401] | PubMed: 37414769 |
Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells [ Cancer Commun (Lond), 2022, 42(8):716-749] | PubMed: 35838183 |
Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells [ Cancer Commun (Lond), 2022, 10.1002/cac2.12332] | PubMed: 35838183 |
ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration [ EMBO J, 2022, e109463] | PubMed: 35229328 |
ATP-citrate lyase inhibitor improves ectopic lipid accumulation in the kidney in a db/db mouse model [ Front Endocrinol (Lausanne), 2022, 13:914865] | PubMed: 36568100 |
[ Cancers (Basel), 2019, ] | PubMed: 31817870 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。