Butylparaben

製品コードS4584 バッチS458401

化学情報

	Synonyms	Butyl parahydroxybenzoate, Butyl paraben, Butyl 4-hydroxybenzoate	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₁H₁₄O₃
	分子量	194.23	CAS No.	94-26-8
Solubility (25°C)*	体外	DMSO	38 mg/mL (195.64 mM)
		Water	38 mg/mL (195.64 mM)
		Ethanol	38 mg/mL (195.64 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Butylparaben (Butyl parahydroxybenzoate, Butyl 4-hydroxybenzoate) is a chemical compound commonly used as an antifungal preservative in cosmetic products.
in vitro	After butylparaben treatment, vimentin filaments in Sertolicells are disrupted. Sertoli cell cytoskeleton responds to butylparaben by exhibiting a marked collapse in vimentin filaments distribution^[1].
in vivo	Butylparaben induces collapse of Sertoli cell vimentin filaments in vivo^[1]. Exposure of a postweaning mammal to butylparaben had an adverse effect on the secretion of testosterone and in the functions of the male reproductive system^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Primary Sertoli cell
	濃度	0, 1, 100 and 1000 nmol/ml
	反応時間	6, 24h
	実験の流れ	Mixed cultures of Sertoli and spermatogenic cells are prepared from three-week-old SD rats. Single cells are obtained by gravity sedimentation and use of 50% trypsin-EDTA. Cells are finally suspended at a concentration of 1 × 10⁸cell/ml and maintained for 24 h in Dulbecco’s modified Eagle medium supplemented with 100 U/ml penicillin, 100 μg/ml streptomycin, and 10% fetal bovineserum. Thereafter, cells are maintained in serum-freemedium, which is changed every 24 h. At 72 h, spermatogenic cells are removed by treatment with hypotonic Tris buffer (20 mMTris–HCl, pH 7.4) for 5 min. The Sertoli cell-enriched cultures obtained are then maintained in serum-free medium for 24 h before being reseeded onto chamber slides. The samples are cultured for a further 5 days. Subsequently, they are exposed to 0, 1, 100 and 1000 nmol/ml butylparaben for 6 and 24 h. Some slides are stained with 0.5% toluidine blue for light microscopic observations, whereas the rest are used for vimentin immuno-histochemical analysis.
動物実験	動物モデル	Male Sprague–Dawley rats
	投薬量	1000 mg/kg
	投与方法	oral administration

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Butyl paraben promotes apoptosis in human trophoblast cells through increased oxidative stress-induced endoplasmic reticulum stress [ Environ Toxicol, 2018, 33(4):436-445]	PubMed: 29319206

Butyl paraben promotes apoptosis in human trophoblast cells through increased oxidative stress-induced endoplasmic reticulum stress [ Environ Toxicol, 2018, 33(4):436-445]

PubMed: 29319206

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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