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Synonyms | Calcipotriol | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C27H40O3 |
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分子量 | 412.60 | CAS No. | 112965-21-6 | |
Solubility (25°C)* | 体外 | DMSO | 83 mg/mL (201.16 mM) | |
Ethanol | 83 mg/mL (201.16 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Calcipotriene (MC903) is a synthetic derivative of calcitriol, a form of vitamin D. It can induce differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and lead to normalization of epidermal growth. |
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in vitro | Calcipotriene enhances IL-10 secretion in psoriatic skin and in human T cells, induces secretion of type 2 cytokines by T cells and, significantly modulates the differentiation of DCs and T cells[1]. |
in vivo | Calcipotriol suppresses skin cancer development in mice in a TSLP-dependent manner. Calcipotriol is a well-tolerated topical medication for psoriasis. The low concentration of calcipotriol in the clinically available formulation (0.005% ointment) dampens its effect against skin cancer development in mice[2]. |
細胞アッセイ | 細胞株 | Monocytes (CD14+ cells)-derived DCs |
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濃度 | 100 nM | |
反応時間 | 24 h or 3 days | |
実験の流れ | Cells are treated in duplicates with 100 nM calcipotriol, 1 mM betamethasone (BDP), combination of calcipotriol and betamethasone (100 nM/1 mM; ratio 1:10 as in the fixed-combination product) or a corresponding vehicle control (0.1% DMSO). Treatment is applied after the first 5 days in culture and before and throughout the 3 days of activation with LPS and IFN-γ or two days after activation with LPS and IFN-γ and throughout the last 24 h of activation. | |
動物実験 | 動物モデル | genetically engineered mouse models |
投薬量 | 80 nM | |
投与方法 | topical |
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Modulation of Skin Inflammatory Responses by Aluminum Adjuvant [ Pharmaceutics, 2023, 15(2)576] | PubMed: 36839900 |
Vitamin D3 suppresses the cholesterol homeostasis pathway in patient-derived glioma cell lines [ FEBS Open Bio, 2023, 13(9):1789-1806] | PubMed: 37489660 |
Vitamin D3 suppresses the cholesterol homeostasis pathway in patient-derived glioma cell lines [ FEBS Open Bio, 2023, 13(9):1789-1806] | PubMed: 37489660 |
Repurposing the natural compounds as potential therapeutic agents for COVID-19 based on the molecular docking study of the main protease and the receptor-binding domain of spike protein [ J Mol Model, 2022, 28(6):153] | PubMed: 35578055 |
Critical Role of TSLP Receptor on CD4 T Cells for Exacerbation of Skin Inflammation [ J Immunol, 2020, 22;ji1900758] | PubMed: 32444388 |
Differential modulation of hepatitis C virus replication and innate immune pathways by synthetic calcitriol-analogs [ J Steroid Biochem Mol Biol, 2018, 183:142-151] | PubMed: 29885880 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。