Calcium D-Panthotenate

製品コードS4503 バッチS450301

印刷

化学情報

Chemical Structure Synonyms D-Pantothenic Acid Calcium Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C18H32CaN2O10
分子量 476.53 CAS No. 137-08-6
Solubility (25°C)* 体外 DMSO 44 mg/mL (92.33 mM)
Water 44 mg/mL (92.33 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Calcium D-Panthotenate (D-Pantothenic Acid Calcium), also called vitamin B5 Calcium, is a water-soluble vitamin and an essential nutrient for many animals.
in vitro Pantothenic acid increases mainly the content of free glutathione, with little effect on protein-boundglutathione in human lymphoblastoic (Jurkat) cells. Pantothenic acid also increases cell respiration with pyruvate as the exogenous substrate.[1] Pantothenic acid belongs to vitamin B group and is the building stone of coenzyme A. Pantothenic acid can be therefore infer that its beneficial effect in various kinds of cell damage by ROS is related to the increased content or stimulated biosynthesis of this coenzyme. Pantothenic acid increases the glutathione content by more than 50% and increases the GSH/GSSG ratio by approximately the same factor. [2] Pantothenic acid and N-acetylcysteine alleviates the ultraviolet-induced decrease of glutathione content, diminished lipid peroxidation, and partly protects the cells against apoptosisproduced by ultraviolet irradiation. [3]
in vivo Pantothenic acid-treated rats exhibited higher basal levels of corticosterone and progesterone than control rats in Adrenal cells. The response of ACTH and/or PRL on corticosterone and progesterone release is higher in the pantothenic acid-treated rats than in the control rats. Pantothenic acid supplementation stimulates the ability of adrenal cells in male rats to secrete corticosterone and progesterone. Pantothenic acid supplementation induces adrenalhyperresponsiveness to ACTH stimulation, and PRL further stimulated adrenal sensitivity to ACTH. [4] Pantothenic acid prior to valproic acid (VPA) significantly protects against VPA-induced neural tube defects (NTDs) in CD-1mice. Pantothenic acid prevents VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb in CD-1 mice. [5]

プロトコル(参考用のみ)

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。