Cangrelor Tetrasodium

製品コードS3737 バッチS373701

印刷

化学情報

Chemical Structure Synonyms AR-C69931MX Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

21Cl2F3N5O12P3S2.4Na
分子量 864.29 CAS No. 163706-36-3
Solubility (25°C)* 体外 Water 100 mg/mL (115.7 mM)
DMSO 2 mg/mL (2.31 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Cangrelor (AR-C69931MX) is a potent, competitive P2Y12 receptor inhibitor that is administered by intravenous infusion and rapidly achieves near complete inhibition of ADP-induced platelet aggregation.
in vitro Cangrelor is an intravenous ATP analog that directly inhibits, without the need for being metabolized, the P2Y12 receptor in a reversible manner. Cangrelor has a rapid-onset and -offset mechanism of action and achieves significantly greater degrees of platelet inhibition compared with clopidogrel[1].
in vivo Cangrelor is rapidly deactivated by plasmatic ectonucleotidases and, thus, has an extrmely short half-life (2-5 min). Preclinical studies performed in animal models in the early stages of cangrelor development show efficacy in inhibiting thrombus formation and ADP-induced platelet aggregation, as well as a lower increase of bleeding times when compared with IIb/IIIa antagonist[1].

プロトコル(参考用のみ)

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Enhanced metabolic activation of and platelet response to clopidogrel in T cell-deficient mice through induction of Cyp2c and Cyp3a and inhibition of Ces1 [ J Thromb Haemost, 2023, S1538-7836(23)00082-X] PubMed: 36738827
Ginsenosides Rb2 and Rd2 isolated from Panax notoginseng flowers attenuate platelet function through P2Y12-mediated cAMP/PKA and PI3K/Akt/Erk1/2 signaling [ Food Funct, 2021, 10.1039/d1fo00531f] PubMed: 34041517
Lipid rafts are essential for release of phosphatidylserine-exposing extracellular vesicles from platelets. [ Sci Rep, 2018, 8(1):9987] PubMed: 29968812

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。