Carbenoxolone Sodium

製品コードS4368 バッチS436801

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₃₄H₄₈Na₂O₇
	分子量	614.72	CAS No.	7421-40-1
Solubility (25°C)*	体外	DMSO	23 mg/mL warmed with 50ºC water bath (37.41 mM)
		Ethanol	6 mg/mL warmed with 50ºC water bath (9.76 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Carbenoxolone, a synthetic derivative of glycyrrhetinic acid, is also used as a blocker of the enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD), of pannexon membrane channels (comprising 6 subunits of pannexin) and the related innexon channels.
in vitro	Carbenoxolone induces astrocytes a reversible suppression of spontaneous action potential discharges, synaptic currents and synchronised calcium oscillations. Carbenoxolone inhibits oscillatory activity induced by the GABAA antagonist, bicuculline.Carbenoxolone causes an increase in the action potential threshold and strongly decreases the firing rate in response to a sustained depolarising current in astrocytes. ^[1] Carbenoxolone (100 μM) reduces photoreceptor-to-horizontal cell synaptic transmission by 92% in the Retina. Carbenoxolone (100 μM) reduces cone Ca channel current by 37%, reduces depolarization-evoked [Ca²⁺] signals in fluo-4 loaded retinal slices by 57% and inhibits Ca channels in Müller cells by 52% in the Retina. ^[2] Carbenoxolone abolishes the generation of full or partial ectopic spike generation, by 4-aminopyridine, as well as spontaneous epileptiform activity in CA3 or CA1 regions of the rat hippocampal slices via closing GJ channels. ^[3]
in vivo	Carbenoxolone (400 mg/kg) decreases the duration of seizure producing protection against seizure but failing to protect against mortality in comparison with diazepam.Carbenoxolone significantly increases sleeping time and decreased latency in doses of 100 mg/kg, 200 mg/kg and 300 mg/kg in mice dose dependently. Carbenoxolone (400 mg/kg) shows muscle relaxant activity and in the accelerated rotarod test, Carbenoxolone in doses of 200 mg/kg and 300 mg/kg shows a decline in motor coordination. ^[3] Carbenoxolone (12.5 mg/day) leads to a significant reduction in average birth weight (20% fall) in rats. ^[4] Carbenoxolone treatment lowers birthweight and induces hypertension in the offspring of rats fed a protein-replete diet. ^[5]

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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