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Synonyms | Salvin | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C20H28O4 |
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分子量 | 332.43 | CAS No. | 3650-09-7 | |
Solubility (25°C)* | 体外 | DMSO | 66 mg/mL (198.53 mM) | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Carnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries. |
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in vitro | Carnosic acid (CA) would inhibit the cell viability of three CRC cell lines: Caco-2, HT29 and LoVo in a dose-dependent manner, with IC50 values in the range of 24-96 μM. CA induces cell death by apoptosis in Caco-2 line after 24 h of treatment and inhibits cell adhesion and migration, possibly by reducing the activity of secreted proteases such as urokinase plasminogen activator (uPA) and metalloproteinases (MMPs). CA downregulates the expression of COX-2 in Caco-2 cells at both the mRNA and protein levels[1]. CA induces antioxidant and anti-inflammatory effects in several cell types, as observed in both in vitro and in vivo experimental models. It exhibits the ability to promote mitochondrial protection in neural cells[2]. In vitro, CA suppresses Receptor Activator for Nuclear Factor-κ B Ligand (RANKL)- and Macrophage colony-stimulating factor (M-CSF)-induced osteoclastogenesis. The osteoclastic specific markers are inhibited by CA. Signal transduction studies show that CA significantly decreases the expression of molecules contributing to ROS and increases anti-oxidants. Additionally, CA inactivates the RANKL- and M-CSF-induced p38 mitogen activated protein kinases (MAPK), inhibits NF-κB phosphorylation, causing pro-inflammatory cytokines down-regulation. CA ameliorates acute promyelocytic leukemia cells through activating nuclear transcription factor E2-related factor 2 (Nrf2), which plays an essential role in cytoprotective responses to oxidative stress[3]. |
in vivo | CA significantly down-regulates fasting blood glucose, glucose level in oral glucose tolerance test (OGTT) and insulin tolerance test (ITT), ameliorates CIA-induced bone loss, and reduces pro-inflammatory cytokines and reactive oxygen species (ROS) in db/db mice with arthritis induced by collagen-induced arthritis (CIA). CA could regulate ER stress to ameliorate disease progression. It can also cross the blood-brain barrier readily and exert its protective effects via its potent anti-oxidative role[3]. |
細胞アッセイ | 細胞株 | Human colon carcinoma cell lines, Caco-2, HT29 and LoVo |
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濃度 | 0 to 388 μM | |
反応時間 | 24 h | |
実験の流れ | Cells (1×104) are seeded in 96-well microplates in complete medium. After 48 h, cells are washed twice with PBS and treated with RE, RA and CA (concentration range from 0 to 388 μM) in complete medium for 24 h. Cell viability is assessed. | |
動物実験 | 動物モデル | male C57BL/KsJ-db/db (db/db) mice |
投薬量 | 30 mg/kg and 60 mg/kg | |
投与方法 | i.p. |
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Pilot-Scale Antioxidant Dipping of Herring (Clupea harengus) Co-products to Allow Their Upgrading to a High-Quality Mince for Food Production [ ACS Sustain Chem Eng, 2023, 11(12):4727-4737] | PubMed: 37013165 |
NQO1 Is a Determinant for Cellular Sensitivity to Anti-Tumor Agent Napabucasin [ Am J Cancer Res, 2020, 1;10(5):1442-1454] | PubMed: 32509390 |
Carnosic acid improves porcine early embryonic development by inhibiting the accumulation of reactive oxygen species [ J Reprod Dev, 2020, 10.1262/jrd.2020-086] | PubMed: 33055461 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
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