Carvacrol

製品コードS3788 バッチS378801

印刷

化学情報

Chemical Structure Synonyms cymophenol Storage
(From the date of receipt)		 2 years -80°C liquid
化学式

C10H14O
分子量 150.22 CAS No. 499-75-2
Solubility (25°C)* 体外  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

生物活性

製品説明 Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.
in vitro Carvacrol (CVC) possesses weak antioxidant and cytotoxic activity in cultured primary rat neurons. In addition, Carvacrol has weak antioxidant properties and little anticancer potentials in rat N2a neuroblastoma cell line[1]. Carvacrol is a novel inhibitor of transient receptor potential (TRP) channels in drosophila and mammalian. In human hepatoma HepG2 cells, Carvacrol induces cell apoptosis by selectively decreasing phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and P38; In human macrophage-like U937 cells, in response to lipopolysaccharide treatment, Carvacrol activates peroxisome proliferator-activated receptors (PPAR alpha and gamma) and suppresses cyclooxygenase-2 (COX-2) mRNA and protein expression[2].
in vivo Carvacrol has the ability to protect liver against ischemia/reperfusion injury in rats. In the central nervous system, Carvacrol is regarded as a potential drug for Alzheimer's disease due to its inhibitory effect on acetylcholinesterase (AChE) activity by using phenolic hydroxyl group of carvacrol to bind to AChE and leading to a loss of function of AChE. In addition, Carvacrol is found to have an antidepressant-like effect in mice by affecting the dopaminergic system. Dietary carvacrol supplementation prevents high fat diet-induced obesity by modulating gene expressions that lead to adipogenesis and inflammation. Carvacrol crosses the blood-brain barrier easily and rapidly[2].
密度 0.976 g/mL at 20 °C

プロトコル(参考用のみ)

細胞アッセイ 細胞株 cultured primary rat neurons and N2a neuroblastoma cells
濃度 10, 25, 50, 100, 200 and 400 mg/L
反応時間 24 h
実験の流れ The cells are seeded in 48-well plates. Cells are incubated at 37 °C in a humidified 5 % CO2/95 % air mixture and treated with carvacrol at different concentrations (10, 25, 50, 100, 200 and 400 mg/L) for 24 h. MTT substrate solution is used. Briefly, MTT is added to the cell cultures for 3 h. Formed formazan crystals are dissolved in dimethyl sulfoxide (DMSO), MTT is added to the cell cultures for 3 h. Formed formazan crystals are dissolved in dimethyl sulfoxide (DMSO).
動物実験 動物モデル Male ICR mice
投薬量 50 mg/kg
投与方法 i.c.v.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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