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Synonyms | CDDO-Imidazolide, TP-235 | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C34H43N3O3
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分子量 | 541.72 | CAS No. | 443104-02-7 | |
Solubility (25°C)* | 体外 | DMSO | 56 mg/mL (103.37 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | CDDO-Im (RTA-403) is an activator of nuclear factor erythroid 2–related factor 2 (Nrf2) and peroxisome proliferator-activated receptor (PPAR). CDDO-Im binds to PPARα and PPARγ with Ki of 232 nM and 344 nM, respectively. CDDO-Im inhibits inflammatory response and tumor growth in vivo. |
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in vitro | CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines (IC50, 10–30 nM). In U937 leukemia cells, CDDO-Im also induces monocytic differentiation as measured by increased cell surface expression of CD11b and CD36. CDDO-Im has significant actions independent of PPAR transactivation.[2] |
in vivo | CDDO-Im is a novel synthetic triterpenoid more potent than its parent compound (CDDO). In vivo, CDDO-Im is a potent inhibitor of de novo inducible nitric oxide synthase expression in primary mouse macrophages. Moreover, CDDO-Im inhibits growth of B16 murine melanoma and L1210 murine leukemia cells in vivo.[2] |
細胞アッセイ | 細胞株 | U937, THP-1, and HL-60 leukemia cells |
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濃度 | 100 pM to 1 μM | |
反応時間 | 5 days | |
実験の流れ | U937, THP-1, and HL-60 leukemia cells are treated with either control vehicle, CDDO, or CDDO-Im at concentrations ranging from 100 pM to 1 μM, and after 5 days, proliferation is measured by cell counting. |
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動物実験 | 動物モデル | female CD-1 mice, male and female BDF-1 mice |
投薬量 | 1 nmole, 10 nmole | |
投与方法 | IP |
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Melatonin attenuates polystyrene microplastics induced motor neurodevelopmental defect in zebrafish (Danio rerio) by activating nrf2 - isl2a Axis [ Ecotoxicol Environ Saf, 2022, 241:113754] | PubMed: 35709674 |
Genetic Ablation of Nrf2 Exacerbates Neuroinflammation in Ocular Autoimmunity [ Int J Mol Sci, 2022, 23(19)11715] | PubMed: 36233013 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。