Cedrol

製品コードS4938 バッチS493801

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C15H26O
分子量 222.37 CAS No. 77-53-2
Solubility (25°C)* 体外 DMSO 44 mg/mL (197.86 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Cedrol, a natural occuring sesquiterpene alcohol, is a potent competitive inhibitor of CYP2B6-mediated bupropion hydroxylase with inhibition constant (Ki) value of 0.9 μM. It also inhibits CYP3A4-mediated midazolam hydroxylation with a Ki value of 3.4 μM while only weakly inhibits CYP2C8, CYP2C9, and CYP2C19 activities.
in vitro Cedrol is an anti-inflammatory constituent, anti-microbial ingredient and antibiosis agent[1]. Cedrol could accelerate fibroblast growth in a dose-dependent manner and increase the production of type 1 collagen and elastin. Phosphorylation of p42/44 extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and Akt are also markedly increased by the treatment of cedrol, indicating that cedrol stimulates ECM production[3]. Cedrol is a potent competitive inhibitor of CYP2B6-mediated bupropion hydroxylase with inhibition constant (Ki) value of 0.9 μM. It also inhibits CYP3A4-mediated midazolam hydroxylation with a Ki value of 3.4 μM while only weakly inhibits CYP2C8, CYP2C9, and CYP2C19 activities[2].
in vivo Cedrol can promote hair reproduction. It promotes hair regeneration and shortens the telogen phase of hair follicles after alopecia occurs. Cedrol may possess a latent ability of preventing damage to initiatory hair follicle and restoring the morphological characteristics of follicles after they have been damaged by chemotherapy. Cedrol is a PAF (platelet-activating factor) antagonist that can reduce or inhibit platelet aggregation, skin inflammation, and vascular disorders[1].

プロトコル(参考用のみ)

動物実験 動物モデル adult female C57BL/6 mice aging 6 weeks
投薬量 50, 100, 200 mg/kg
投与方法 topically

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。