Chlorocresol

製品コードS4209 バッチS420901

化学情報

	Synonyms	4-Chloro-3-methylphenol,PCMC	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₇H₇ClO
	分子量	142.58	CAS No.	59-50-7
Solubility (25°C)*	体外	DMSO	29 mg/mL (203.39 mM)
		Ethanol	29 mg/mL (203.39 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Chlorocresol(4-Chloro-3-methylphenol,PCMC) is an activator of ryanodine receptor.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
in vitro	Chlorocresol (1 mM) is capable of releasing Ca²⁺ from a ruthenium red/caffeine-sensitive Ca²⁺ release channel selectively localized in terminal cistemae (TC), whereas Chlorocresol has no effect on longitudinal sarcoplasmic reticulum (LSR), indicating that Chlorocresol is not acting by inhibiting the Ca²⁺-ATPase or damaging the vesicles. Chlorocresol is capable of releasing Ca²⁺ from heparmn-treated cerebellar microsomes. In PC12 cells, Chlorocresol releases Ca²⁺ from a caffeine/thapsigargin- sensitive intracellular store. The chloro and methyl groups in Chlorocresols are important for the activation of the ryanodine receptor Ca²⁺ release channel. ^[1] Chlorocresol causes muscle contracture in malignant hyperthermia-susceptible (MHS) muscles at a concentration of 25–50 mM and potentiates the caffeine contracture response in human MHS muscles. Sub-threshold (20 mM) concentrations of Chlorocresol increases both the K_d (6.0 vs. 10 mM) and the V_max (2.2 vs. 1.55 mmol Ca²⁺/min/mg protein) of caffeine-induced Ca²⁺ release from isolated rabbit terminal cisternae. ^[2]

製品説明

Chlorocresol(4-Chloro-3-methylphenol,PCMC) is an activator of ryanodine receptor.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

in vitro

Chlorocresol (1 mM) is capable of releasing Ca²⁺ from a ruthenium red/caffeine-sensitive Ca²⁺ release channel selectively localized in terminal cistemae (TC), whereas Chlorocresol has no effect on longitudinal sarcoplasmic reticulum (LSR), indicating that Chlorocresol is not acting by inhibiting the Ca²⁺-ATPase or damaging the vesicles. Chlorocresol is capable of releasing Ca²⁺ from heparmn-treated cerebellar microsomes. In PC12 cells, Chlorocresol releases Ca²⁺ from a caffeine/thapsigargin- sensitive intracellular store. The chloro and methyl groups in Chlorocresols are important for the activation of the ryanodine receptor Ca²⁺ release channel. ^[1] Chlorocresol causes muscle contracture in malignant hyperthermia-susceptible (MHS) muscles at a concentration of 25–50 mM and potentiates the caffeine contracture response in human MHS muscles. Sub-threshold (20 mM) concentrations of Chlorocresol increases both the K_d (6.0 vs. 10 mM) and the V_max (2.2 vs. 1.55 mmol Ca²⁺/min/mg protein) of caffeine-induced Ca²⁺ release from isolated rabbit terminal cisternae. ^[2]

プロトコル(参考用のみ)

参考

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。