Cinnarizine

製品コードS4727 バッチS472701

印刷

化学情報

Chemical Structure Synonyms Stugeron, Dimitronal, Stutgin, Cinarizine Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C26H28N2
分子量 368.51 CAS No. 298-57-7
Solubility (25°C)* 体外 DMSO 9.1 mg/mL (24.69 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Cinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine) is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.
in vitro Cinnarizine inhibits melanogenesis in B16 cells by a dose-dependent manner at the non-cytotoxic concentrations and is a histamine receptor antagonists[3].
in vivo Cinnarizine has anticonvulsive properties in rats and mice. It could provide a direct neuroprotective effect against the damaging influx of calcium and also prevent neuronal damage as a result of MES- and PTZ-induced seizures[2]. Cinnarizine induces behavioural changes such as alopecia, bucolingual dyskinesia and reduction of motor activity in female parkin knock out (PK-KO) mice but not in wild-type (WT) controls.PK-KO mice have high striatal dopamine levels and increased dopamine metabolism in spite of low reduced tyrosine hydroxylase protein. Cinnarizine, which blocks dopamine receptors and increases dopamine release, further increased dopamine metabolism[3]. Its half-life is 4 hours.

プロトコル(参考用のみ)

細胞アッセイ 細胞株 mouse B16 melanoma cells(4A5)
濃度 0.625, 1.25, 2.5, 5, 10, 20 μM
反応時間 48 h
実験の流れ MTT assay is performed to examine the viability of cells. Afterwards, the cells are incubated with the samples for 48 h, the culture medium is removed and replaced with 1 mg/mL MTT solution dissolved in phosphate-buffered saline (PBS) and incubated for an additional 2 h. The MTT solution is then removed and DMSO was added, following which the absorbance of the dissolved formazan crystals is determined at 570 nm by a spectrophotometer.
動物実験 動物モデル Male albino mice
投薬量 30 mg/kg
投与方法 i.p

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms [ Sci Adv, 2022, 8(15):eabk2376] PubMed: 35417232

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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