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Synonyms | Storage (From the date of receipt) |
3 years -20°C powder | ||
化学式 | C18H19ClN4O |
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分子量 | 342.82 | CAS No. | 34233-69-7 | |
Solubility (25°C)* | 体外 | DMSO | 68 mg/mL (198.35 mM) | |
Water | 68 mg/mL warmed with 50ºC water bath (198.35 mM) | |||
Ethanol | 8 mg/mL (23.33 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | CNO (Clozapine N-oxide) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist.Solutions are unstable and should be fresh-prepared. |
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in vitro | CNO is a synthetic small molecule actuator for muscarinic acetylcholine DREADDs. |
in vivo | Clozapine N-oxide (CNO), an agonist of human muscarinic designer receptor (DREADDs), is converted to clozapine and exerts clozapine-like behavioral effects in both mice and rats further emphasizes the need for appropriate control groups in studies employing DREADDs.[4] |
細胞アッセイ | 細胞株 | CHO cells |
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濃度 | pEC50 8.31 | |
反応時間 | ||
実験の流れ | ||
動物実験 | 動物モデル | standard laboratory rats and mice |
投薬量 | 1.0, 3.2, 10.0 mg/kg for rats; 1.25, 2.5, 5.0, 10.0, 20.0 mg/kg for mice | |
投与方法 | i.p. |
Stress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion [ Nat Commun, 2023, 10.1038/s41467-023-42814-1] | PubMed: 37903803 |
Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice [ Nat Commun, 2023, 14(1):71] | PubMed: 36604429 |
Stress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion [ Nat Commun, 2023, 14(1):6923] | PubMed: 37903803 |
Tet2 acts in the lateral habenula to regulate social preference in mice [ Cell Rep, 2023, 42(7):112695] | PubMed: 37402169 |
Excitatory neurons in the lateral parabrachial nucleus mediate the interruptive effect of inflammatory pain on a sustained attention task [ J Transl Med, 2023, 21(1):896] | PubMed: 38072957 |
Activation of astrocyte Gq pathway in hippocampal CA1 region attenuates anesthesia/surgery induced cognitive dysfunction in aged mice [ Front Aging Neurosci, 2022, 14:1040569] | PubMed: 36437995 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。